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Gm960 Gene Detail
Summary
  • Symbol
    Gm960
  • Name
    predicted gene 960
  • Synonyms
    Top6bl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685806
    NCBI Gene: 381196
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr19:4625734-4698668 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    435 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685806
protein coding gene Chr19:4625734-4698776 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024669
protein coding gene Chr19:1513009-1587632 (-)
A/J MGP_AJ_G0024635
protein coding gene Chr19:1436058-1515419 (-)
AKR/J MGP_AKRJ_G0024608
protein coding gene Chr19:1477900-1552109 (-)
BALB/cJ MGP_BALBcJ_G0024635
protein coding gene Chr19:1431355-1505801 (-)
C3H/HeJ MGP_C3HHeJ_G0024403
protein coding gene Chr19:1484788-1559716 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0022512
protein coding gene Chr19:1371168-1445415 (-)
CAST/EiJ MGP_CASTEiJ_G0023875
protein coding gene Chr19:1495026-1575487 (-)
CBA/J MGP_CBAJ_G0024374
protein coding gene Chr19:1632426-1712366 (-)
DBA/2J MGP_DBA2J_G0024502
protein coding gene Chr19:1400074-1473106 (-)
FVB/NJ MGP_FVBNJ_G0024469
protein coding gene Chr19:1426222-1501633 (-)
LP/J MGP_LPJ_G0024588
protein coding gene Chr19:1521655-1595518 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024499
protein coding gene Chr19:1546427-1619673 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025130
protein coding gene Chr19:1476590-1553155 (-)
PWK/PhJ MGP_PWKPhJ_G0023621
protein coding gene Chr19:1458404-1526579 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023426
protein coding gene Chr19:1468631-1544380 (-)
WSB/EiJ MGP_WSBEiJ_G0023937
protein coding gene Chr19:1472223-1547092 (-)



Homology
more
  • Human Ortholog
    C11orf80, chromosome 11 open reading frame 80
  • Vertebrate Orthologs
    7
  • Human Ortholog
    C11orf80, chromosome 11 open reading frame 80
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TOP6BL, TOPOVIBL
  • Links
    NCBI Gene ID: 79703
    neXtProt AC: NX_Q8N6T0
    UniProt: Q8N6T0

  • Chr Location
    11q13.2; chr11:66744736-66843516 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired double-strand break formation that imapires female and male meiosis and results in no spermatids and reduced primary and primordial follicle numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071691 Ensembl Gene Model | MGI Sequence Detail 72935 C57BL/6J ±  kb
    transcript ENSMUST00000177696 Ensembl | MGI Sequence Detail 2262 Not Applicable  
    polypeptide ENSMUSP00000136515 Ensembl | MGI Sequence Detail 753 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR028040 Type 2 DNA topoisomerase 6 subunit B-like
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 4
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 16
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 3
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:229524 Robert T, et al., The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. 2016 Feb 26;351(6276):943-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory