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Cplx4
Gene Detail
Symbol

Name
ID
Cplx4
complexin 4
MGI:2685803
Synonyms
A930004D23Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 18
39.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:65955727-65970178 bp, - strand
From Ensembl annotation of GRCm38

  14452 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CPLX4
Gene Tree: Cplx4

Human
homologs
CPLX4, complexin 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 339302
neXtProt AC: NX_Q7Z7G2

Human Synonyms: CPXIV, CPX-IV

Human Chr (Location): 18q21.32; chr18:59295402-59318649 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation are viable and fertile displaying only slight abnormalities in eye electrophysiology.
 
Interactions
Cplx4 interacts with 176 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process exocytosis, neurotransmitter transport, ...
Component cell junction, membrane, ...
Function SNARE binding, syntaxin binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (11)    Tissues (8)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cplx4 ; ZFIN cplx4a    NEW 
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000024519 (Evidence)
Entrez Gene 225644 (Evidence)
UniGene 192285
DFCI TC1585229
DoTS DT.91335345
NIA Mouse Gene Index U161827
Consensus CDS Project CCDS29312.1
International Mouse Phenotyping Consortium Status Cplx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024519 Ensembl Gene Model | MGI Sequence Detail 14452 C57BL/6J ±  kb
transcript ENSMUST00000025397 Ensembl | MGI Sequence Detail 1751 Not Applicable 
polypeptide ENSMUSP00000025397 Ensembl | MGI Sequence Detail 160 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008849 Synaphin
Protein Ontology PR:000005812 complexin-4
References
(Earliest) J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
(Latest) J:207661 Landgraf I, et al., The absence of Complexin 3 and Complexin 4 differentially impacts the ON and OFF pathways in mouse retina. Eur J Neurosci. 2012 Aug;36(4):2470-81
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory