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Npw Gene Detail
Summary
  • Symbol
    Npw
  • Name
    neuropeptide W
  • Synonyms
    LOC381073
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685781
    NCBI Gene: 381073
  • Gene Overview
    MyGene.info: NPW
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24657330-24658425 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685781
protein coding gene Chr17:24657330-24658457 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023311
protein coding gene Chr17:23656342-23657478 (-)
A/J MGP_AJ_G0023271
protein coding gene Chr17:23016416-23017552 (-)
AKR/J MGP_AKRJ_G0023238
protein coding gene Chr17:23096721-23097857 (-)
BALB/cJ MGP_BALBcJ_G0023276
protein coding gene Chr17:23201808-23202944 (-)
C3H/HeJ MGP_C3HHeJ_G0023036
protein coding gene Chr17:23456655-23457791 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023720
protein coding gene Chr17:24707686-24708813 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021195
protein coding gene Chr17:20490286-20491408 (-)
CAST/EiJ MGP_CASTEiJ_G0022538
protein coding gene Chr17:23308583-23309721 (-)
CBA/J MGP_CBAJ_G0023012
protein coding gene Chr17:25549828-25550964 (-)
DBA/2J MGP_DBA2J_G0023141
protein coding gene Chr17:22605123-22606259 (-)
FVB/NJ MGP_FVBNJ_G0023111
protein coding gene Chr17:22328950-22330088 (-)
LP/J MGP_LPJ_G0023218
protein coding gene Chr17:23967978-23969114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023130
protein coding gene Chr17:25259022-25260158 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023757
protein coding gene Chr17:23375423-23376559 (-)
PWK/PhJ MGP_PWKPhJ_G0022287
protein coding gene Chr17:21353535-21354662 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022105
protein coding gene Chr17:21416346-21417487 (-)
WSB/EiJ MGP_WSBEiJ_G0022601
protein coding gene Chr17:23441845-23442982 (-)



Homology
more
  • Human Ortholog
    NPW, neuropeptide W
  • Vertebrate Orthologs
    5
  • Human Ortholog
    NPW, neuropeptide W
    Orthology source: HomoloGene, HGNC
  • Synonyms
    L8, L8C, PPL8, PPNPW
  • Links
    NCBI Gene ID: 283869
    neXtProt AC: NX_Q8N729
    UniProt: Q8N729

  • Chr Location
    16p13.3; chr16:2019520-2020755 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 381073 NCBI Gene Model | MGI Sequence Detail 1096 C57BL/6J ±  kb
transcript NM_001099664 RefSeq | MGI Sequence Detail 606 C57BL/6  
polypeptide NP_001093134 RefSeq | MGI Sequence Detail 176 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR013297 Neuropeptide B/W precursor family
    IPR013299 Neuropeptide W precursor
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 21
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:248800 Wang R, et al., Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo. Mol Cell Endocrinol. 2017 May 15;447:71-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory