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Npw Gene Detail
Summary
  • Symbol
    Npw
  • Name
    neuropeptide W
  • Synonyms
    LOC381073
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685781
    NCBI Gene: 381073
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24876304-24877431 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685781
 protein coding gene Chr17:24876303-24877526 (-)
129S1/SvImJ ENSMUSG00200045904
 protein coding gene Chr17:20322209-20323345 (-)
A/J ENSMUSG00195047205
 protein coding gene Chr17:21341070-21342206 (-)
AKR/J ENSMUSG00220022916
 protein coding gene Chr17:20387359-20388495 (-)
BALB/cJ ENSMUSG00180046176
 protein coding gene Chr17:20620879-20622015 (-)
C3H/HeJ ENSMUSG00175049399
 protein coding gene Chr17:20379256-20380392 (-)
C57BL/6NJ ENSMUSG00215051891
 protein coding gene Chr17:20384412-20385539 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021195
 protein coding gene Chr17:20490286-20491408 (-)
CAST/EiJ ENSTCUG00005039877
 protein coding gene Chr17:20954309-20955447 (-)
CBA/J ENSMUSG00210050013
 protein coding gene Chr17:20218085-20219221 (-)
DBA/2J ENSMUSG00185043765
 protein coding gene Chr17:22429398-22430534 (-)
FVB/NJ ENSMUSG00205021284
 protein coding gene Chr17:20681039-20682177 (-)
JF1/MsJ ENSUMUG00000017448
 protein coding gene Chr17:21876214-21877341 (-)
LP/J ENSMUSG00230054554
 protein coding gene Chr17:23826860-23827996 (-)
NOD/ShiLtJ ENSMUSG00190048208
 protein coding gene Chr17:20318145-20319281 (-)
NZO/HlLtJ ENSMUSG00225053488
 protein coding gene Chr17:25748527-25749663 (-)
PWK/PhJ ENSLUMG00010017822
 protein coding gene Chr17:19785694-19786821 (-)
SPRET/EiJ ENSMSPG00010047387
 protein coding gene Chr17:21119338-21120479 (-)
WSB/EiJ ENSIUOG00005050515
 protein coding gene Chr17:21066675-21067812 (-)



Homology
more
  • Human Ortholog
    NPW, neuropeptide W
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPW, neuropeptide W
  • Synonyms
    L8, L8C, PPL8, PPNPW
  • Links
    NCBI Gene ID: 283869
    UniProt: Q8N729

  • Chr Location
    16p13.3; chr16:2009926-2020755 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knock-out mice exhibit abnormal response to formalin-induced pain stimuli or a live rat only when placed in a novel environment, failing to show the normal self-protective and aversive reactions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    2
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071230 Ensembl Gene Model | MGI Sequence Detail 1128 C57BL/6J ±  kb
    transcript ENSMUST00000095544 Ensembl | MGI Sequence Detail 638 Not Applicable  
    polypeptide ENSMUSP00000093200 Ensembl | MGI Sequence Detail 176 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR013297 Neuropeptide B/W precursor family
      IPR013299 Neuropeptide W precursor
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:369166 Kim DW, et al., Decoding gene networks controlling hypothalamic and prethalamic neuron development. Cell Rep. 2025 Jun 24;44(6):115858
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory