Fam186a Gene Detail

Summary

• Symbol
  Fam186a
• Name
  family with sequence similarity 186, member A
• Synonyms
  1700030F18Rik, LOC380973

• Feature Type
  protein coding gene
• IDs
  MGI:2685766
  NCBI Gene: 72277
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr15:99918348-99931658 bp, - strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 56.13 cM, cytoband F3
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  136 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685766	protein coding gene	Chr15:99918348-99967061 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022345	protein coding gene	Chr15:101816039-101867919 (-)
A/J	MGP_AJ_G0022303	protein coding gene	Chr15:97754332-97807327 (-)
AKR/J	MGP_AKRJ_G0022279	protein coding gene	Chr15:100756910-100807725 (-)
BALB/cJ	MGP_BALBcJ_G0022309	protein coding gene	Chr15:97923256-97972563 (-)
C3H/HeJ	MGP_C3HHeJ_G0022077	protein coding gene	Chr15:100822076-100877964 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022754	protein coding gene	Chr15:105605797-105657583 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020280	protein coding gene	Chr15:93621381-93633742 (-)
CAST/EiJ	MGP_CASTEiJ_G0021601	protein coding gene	Chr15:101687535-101736904 (-)
CBA/J	MGP_CBAJ_G0022046	protein coding gene	Chr15:109209731-109268096 (-)
DBA/2J	MGP_DBA2J_G0022173	protein coding gene	Chr15:97180112-97193815 (-)
FVB/NJ	MGP_FVBNJ_G0022153	protein coding gene	Chr15:96176878-96224315 (-)
LP/J	MGP_LPJ_G0022244	protein coding gene	Chr15:101953173-102005416 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022173	protein coding gene	Chr15:113078044-113137816 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022769	protein coding gene	Chr15:100873589-100886829 (-)
PWK/PhJ	MGP_PWKPhJ_G0021340	protein coding gene	Chr15:97324089-97374758 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021175	protein coding gene	Chr15:100710623-100764888 (-)
WSB/EiJ	MGP_WSBEiJ_G0021652	protein coding gene	Chr15:101394519-101446920 (-)

Homology

• Human Ortholog
  FAM186A, family with sequence similarity 186 member A

• Human Ortholog
  FAM186A, family with sequence similarity 186 member A
  Orthology source: HGNC
• Links
  HGNC:26980

  NCBI Gene ID: 121006

  neXtProt AC: NX_A6NE01

  UniProt: A6NE01

  
  
• Chr Location
  12q13.12; chr12:50326854-50396633 (-)  GRCh38.p7

---

• HCOP
  human homology predictions: FAM186A
• Gene Tree
  Fam186a
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  21 phenotype references
  

• All Mutations and Alleles
  9
• Chemically induced (other)
  1
• Gene trapped
  6
• Radiation induced
  2
• Genomic Mutations
  3 involving Fam186a
• Incidental Mutations
  APF
• Find Mice (IMSR)
  46 strains or lines available

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• cDNA Data
  8

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Fam186a interacts with 17 markers (Mir30a, Mir30b, Mir30c-1, ...) View All

Sequences &
Gene Models

• All Sequences
  34
• RefSeq
  3
• UniProt
  3
• CCDS
  CCDS37207.1

• Ensembl
  ENSMUSG00000045350 (Evidence)
• NCBI Gene
  72277

Representative Sequences			Length	Strain/Species
genomic	72277	NCBI Gene Model | MGI Sequence Detail	13311	C57BL/6J
transcript	NM_028180	RefSeq | MGI Sequence Detail	621	C57BL/6
polypeptide	Q9D9R9	UniProt | EBI | MGI Sequence Detail	1790	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000032510 protein FAM186A
  (term hierarchy)
• InterPro Domains
  IPR039332 Protein FAM186A/FAM186B

Molecular
Reagents

• All nucleic 8

  cDNA 8

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:1919527

References

• Summaries
  All 42

  Diseases 1

  Phenotypes 21
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

TSS for Fam186a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136410	Chr15:99967081-99967087 (-)	-35,426 bp
Tssr136409	Chr15:99967067-99967077 (-)	-35,414 bp
Tssr136407	Chr15:99931784-99931803 (-)	-136 bp