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Agr3 Gene Detail
Summary
  • Symbol
    Agr3
  • Name
    anterior gradient 3
  • Synonyms
    E030025L21Rik, LOC380754
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685734
    NCBI Gene: 403205
  • Gene Overview
    MyGene.info: AGR3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:35925621-35949737 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 15.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685734
protein coding gene Chr12:35925620-35949737 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019685
protein coding gene Chr12:34130341-34154625 (+)
A/J MGP_AJ_G0019651
protein coding gene Chr12:33069104-33093350 (+)
AKR/J MGP_AKRJ_G0019622
protein coding gene Chr12:34100833-34125089 (+)
BALB/cJ MGP_BALBcJ_G0019629
protein coding gene Chr12:33268101-33292629 (+)
C3H/HeJ MGP_C3HHeJ_G0019433
protein coding gene Chr12:34025937-34050749 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020076
protein coding gene Chr12:35093256-35117360 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017701
protein coding gene Chr12:32178338-32203497 (+)
CAST/EiJ MGP_CASTEiJ_G0018987
protein coding gene Chr12:29081174-29109900 (+)
CBA/J MGP_CBAJ_G0019405
protein coding gene Chr12:36270035-36294097 (+)
DBA/2J MGP_DBA2J_G0019518
protein coding gene Chr12:32912863-32937904 (+)
FVB/NJ MGP_FVBNJ_G0019507
protein coding gene Chr12:32634393-32660171 (+)
LP/J MGP_LPJ_G0019588
protein coding gene Chr12:34217462-34241915 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019543
protein coding gene Chr12:35934567-35960358 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020116
protein coding gene Chr12:33615973-33641200 (+)
PWK/PhJ MGP_PWKPhJ_G0018754
protein coding gene Chr12:27608765-27634234 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018543
protein coding gene Chr12:28248663-28274068 (+)
WSB/EiJ MGP_WSBEiJ_G0019037
protein coding gene Chr12:33859475-33884148 (+)



Homology
more
  • Human Ortholog
    AGR3, anterior gradient 3, protein disulphide isomerase family member
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AGR3, anterior gradient 3, protein disulphide isomerase family member
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AG3, AG-3, BCMP11, hAG-3, HAG3, PDIA18
  • Links
    NCBI Gene ID: 155465
    neXtProt AC: NX_Q8TD06
    UniProt: Q8TD06

  • Chr Location
    7p21.1; chr7:16854711-16881989 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 403205 NCBI Gene Model | MGI Sequence Detail 24117 C57BL/6J ±  kb
transcript NM_207531 RefSeq | MGI Sequence Detail 819 C57BL/6  
polypeptide Q8R3W7 UniProt | EBI | MGI Sequence Detail 165 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 24
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
  • Latest
    J:244117 Bonser LR, et al., The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway. Am J Respir Cell Mol Biol. 2015 Oct;53(4):536-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory