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Spata22 Gene Detail
Summary
  • Symbol
    Spata22
  • Name
    spermatogenesis associated 22
  • Synonyms
    LOC380709
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685728
    NCBI Gene: 380709
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:73329741-73346044 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685728
protein coding gene Chr11:73326560-73346592 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SPATA22, spermatogenesis associated 22
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPATA22, spermatogenesis associated 22
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NYDSP20, NYD-SP20
  • Links
    NCBI Gene ID: 84690
    neXtProt AC: NX_Q8NHS9
    UniProt: Q8NHS9

  • Chr Location
    17p13.2; chr17:3440011-3513852 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 5 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutations of this gene result in small gonads, severe germ cell depletion, and sterility in both males and females due to meiotic prophase I arrest associated with abnormal synaptonemal complex formation, chromosome asynapsis, and impaired double strand break repair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000112920 Ensembl Gene Model | MGI Sequence Detail 16304 C57BL/6J ±  kb
transcript ENSMUST00000092926 Ensembl | MGI Sequence Detail 1274 Not Applicable  
polypeptide ENSMUSP00000090602 Ensembl | MGI Sequence Detail 358 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:279342 Zhang Q, et al., Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome. Nat Commun. 2019 Jul 29;10(1):3387

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory