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Ldc1 Gene Detail
Summary
  • Symbol
    Ldc1
  • Name
    leucine decarboxylase 1
  • Synonyms
    Gm853, LOC332942
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685699
    NCBI Gene: 332942
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:130209109-130222401 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685699
protein coding gene Chr4:130209025-130222428 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028846
protein coding gene Chr4:132202210-132215469 (-)
A/J MGP_AJ_G0028805
protein coding gene Chr4:126901294-126914726 (-)
AKR/J MGP_AKRJ_G0028758
protein coding gene Chr4:130457550-130470595 (-)
BALB/cJ MGP_BALBcJ_G0028828
protein coding gene Chr4:127513132-127526492 (-)
C3H/HeJ MGP_C3HHeJ_G0028542
protein coding gene Chr4:130514072-130527371 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029270
protein coding gene Chr4:137155406-137168690 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026542
protein coding gene Chr4:120017525-120030877 (-)
CAST/EiJ MGP_CASTEiJ_G0027974
protein coding gene Chr4:128724292-128738425 (-)
CBA/J MGP_CBAJ_G0028508
protein coding gene Chr4:140636731-140650014 (-)
DBA/2J MGP_DBA2J_G0028657
protein coding gene Chr4:127335466-127348761 (-)
FVB/NJ MGP_FVBNJ_G0028624
protein coding gene Chr4:126121953-126135073 (-)
LP/J MGP_LPJ_G0028758
protein coding gene Chr4:132528811-132542134 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028650
protein coding gene Chr4:145346304-145359908 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029308
protein coding gene Chr4:130823259-130836553 (-)
PWK/PhJ MGP_PWKPhJ_G0027696
protein coding gene Chr4:123960433-123972567 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027522
protein coding gene Chr4:126694925-126707752 (-)
WSB/EiJ MGP_WSBEiJ_G0028055
protein coding gene Chr4:130976159-130990204 (-)



Homology
more
  • Human Ortholog
    LDC1P, leucine decarboxylase 1, pseudogene
  • Vertebrate Orthologs
    4
  • Human Ortholog
    LDC1P, leucine decarboxylase 1, pseudogene
    Orthology source: HGNC
  • Synonyms
    LINC01225
  • Links
    NCBI Gene ID: 149086

  • Chr Location
    1p35.2; chr1:31500085-31508566 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023120 Ensembl Gene Model | MGI Sequence Detail 13293 C57BL/6J ±  kb
transcript ENSMUST00000023884 Ensembl | MGI Sequence Detail 2314 Not Applicable  
polypeptide ENSMUSP00000023884 Ensembl | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR009006 Alanine racemase/group IV decarboxylase, C-terminal
    IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site
    IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal
    IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal
    IPR022653 Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site
    IPR000183 Ornithine/DAP/Arg decarboxylase
    IPR002433 Ornithine decarboxylase
    IPR029066 PLP-binding barrel
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 1
Other
Accession IDs
less
MGI:3841243
References
more
  • Summaries
    All 19
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:255630 Lambertos A, et al., The mouse Gm853 gene encodes a novel enzyme: Leucine decarboxylase. Biochim Biophys Acta. 2017 Nov 4;1862(3):365-376

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory