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Frem3 Gene Detail
Summary
  • Symbol
    Frem3
  • Name
    Fras1 related extracellular matrix protein 3
  • Synonyms
    LOC333315
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685641
    NCBI Gene: 333315
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr8:80611080-80695356 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 38.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    402 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685641
protein coding gene Chr8:80611039-80695557 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033818
protein coding gene Chr8:81340510-81418509 (+)
A/J MGP_AJ_G0033800
protein coding gene Chr8:78098157-78175221 (+)
AKR/J MGP_AKRJ_G0033727
protein coding gene Chr8:80444710-80526390 (+)
BALB/cJ MGP_BALBcJ_G0033794
protein coding gene Chr8:78209242-78290147 (+)
C3H/HeJ MGP_C3HHeJ_G0033503
protein coding gene Chr8:81071730-81156930 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034314
protein coding gene Chr8:84465825-84561304 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031255
protein coding gene Chr8:72114681-72188748 (+)
CAST/EiJ MGP_CASTEiJ_G0032834
protein coding gene Chr8:80411636-80481269 (+)
CBA/J MGP_CBAJ_G0033482
protein coding gene Chr8:87456544-87549653 (+)
DBA/2J MGP_DBA2J_G0033635
protein coding gene Chr8:77790020-77862732 (+)
FVB/NJ MGP_FVBNJ_G0033580
protein coding gene Chr8:76732317-76816874 (+)
LP/J MGP_LPJ_G0033725
protein coding gene Chr8:81434446-81507715 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033623
protein coding gene Chr8:89950062-90028281 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034331
protein coding gene Chr8:80449184-80527431 (+)
PWK/PhJ MGP_PWKPhJ_G0032537
protein coding gene Chr8:77047418-77119337 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032375
protein coding gene Chr8:79259088-79337892 (+)
WSB/EiJ MGP_WSBEiJ_G0032947
protein coding gene Chr8:80797260-80883135 (+)



Homology
more
  • Human Ortholog
    FREM3, FRAS1 related extracellular matrix 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FREM3, FRAS1 related extracellular matrix 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 166752
    neXtProt AC: NX_P0C091
    UniProt: P0C091

  • Chr Location
    4q31.21; chr4:143577407-143700675 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042353 Ensembl Gene Model | MGI Sequence Detail 84277 C57BL/6J ±  kb
transcript ENSMUST00000039695 Ensembl | MGI Sequence Detail 6384 Not Applicable  
polypeptide ENSMUSP00000038015 Ensembl | MGI Sequence Detail 2127 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 1
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 48
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 28
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
  • Latest
    J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory