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Card9 Gene Detail
Summary
  • Symbol
    Card9
  • Name
    caspase recruitment domain family, member 9
  • Synonyms
    LOC332579
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685628
    NCBI Gene: 332579
  • Gene Overview
    MyGene.info: CARD9
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:26352176-26360918 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 18.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685628
protein coding gene Chr2:26352176-26361530 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025484
protein coding gene Chr2:24300431-24309254 (-)
A/J MGP_AJ_G0025461
protein coding gene Chr2:23369411-23378139 (-)
AKR/J MGP_AKRJ_G0025431
protein coding gene Chr2:24131544-24140278 (-)
BALB/cJ MGP_BALBcJ_G0025457
protein coding gene Chr2:23478059-23486852 (-)
C3H/HeJ MGP_C3HHeJ_G0025218
protein coding gene Chr2:24089118-24097857 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025901
protein coding gene Chr2:25084186-25092924 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023312
protein coding gene Chr2:22248182-22257145 (-)
CAST/EiJ MGP_CASTEiJ_G0024681
protein coding gene Chr2:23963121-23971940 (-)
CBA/J MGP_CBAJ_G0025196
protein coding gene Chr2:25930174-25942312 (-)
DBA/2J MGP_DBA2J_G0025329
protein coding gene Chr2:23191031-23199768 (-)
FVB/NJ MGP_FVBNJ_G0025291
protein coding gene Chr2:22942695-22951437 (-)
LP/J MGP_LPJ_G0025415
protein coding gene Chr2:24246905-24255728 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025322
protein coding gene Chr2:26083307-26092043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025960
protein coding gene Chr2:24087810-24096630 (-)
PWK/PhJ MGP_PWKPhJ_G0024429
protein coding gene Chr2:22993919-23002682 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024229
protein coding gene Chr2:24217913-24226563 (-)
WSB/EiJ MGP_WSBEiJ_G0024750
protein coding gene Chr2:24195981-24204712 (-)



Homology
more
  • Human Ortholog
    CARD9, caspase recruitment domain family member 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CARD9, caspase recruitment domain family member 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CANDF2, hCARD9
  • Links
    NCBI Gene ID: 64170
    neXtProt AC: NX_Q9H257
    UniProt: Q9H257

  • Chr Location
    9q34.3; chr9:136363956-136373681 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CARD9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one allele of this gene display impaired immune responses to fungal infection but normal rates of bacterial clearance. However, homozygotes for a second allele display impaired bacterial clearance and impaired early innate immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026928 Ensembl Gene Model | MGI Sequence Detail 8743 C57BL/6J ±  kb
transcript ENSMUST00000100303 Ensembl | MGI Sequence Detail 1947 Not Applicable  
polypeptide ENSMUSP00000097876 Ensembl | MGI Sequence Detail 536 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 1
References
more
  • Summaries
    All 80
    Gene Ontology 6
    Phenotypes 58
  • Earliest
    J:111706 Gross O, et al., Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature. 2006 Aug 10;442(7103):651-6
  • Latest
    J:262951 Qin X, et al., Caspase recruitment domain-containing protein 9 (CARD9) knockout reduces regional ischemia/reperfusion injury through an attenuated inflammatory response. PLoS One. 2018;13(6):e0199711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory