Card9
Gene Detail

Symbol Name ID

Card9 caspase recruitment domain family, member 9 MGI:2685628

Synonyms

LOC332579

Feature Type

protein coding gene

Genetic Map

Chromosome 2

18.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:26352187-26360918 bp, - strand From VEGA annotation of GRCm38   8732 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: caspase recruitment domain-containing protein 9
Gene Tree: Card9

Human homologs

Human Homolog		CARD9, caspase recruitment domain family, member 9
NCBI Gene ID		64170
neXtProt AC		NX_Q9H257
Human Synonyms		CANDF2, hCARD9
Human Chr (Location)		9q34.3; chr9:139258408-139268133 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CARD9

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Mice homozygous for one allele of this gene display impaired immune responses to fungal infection but normal rates of bacterial clearance. However, homozygotes for a second allele display impaired bacterial clearance and impaired early innate immune responses.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	defense response to Gram-positive bacterium, defense response to virus, ...
Component	cytoplasm
Function	CARD domain binding, protein binding, ...

External Resources: FuncBase

Expression

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Other(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000012770 (Evidence)
Ensembl Gene Model	ENSMUSG00000026928 (Evidence)
Entrez Gene	332579 (Evidence)
UniGene	330064
DFCI	TC1592767
DoTS	DT.97366742
NIA Mouse Gene Index	U276900
Consensus CDS Project	CCDS38084.1
International Mouse Knockout Project Status	Card9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012770	VEGA Gene Model | MGI Sequence Detail	8732	C57BL/6J
transcript	OTTMUST00000030553	VEGA | MGI Sequence Detail	1880	Not Applicable
polypeptide	OTTMUSP00000013722	VEGA | MGI Sequence Detail	536	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(53 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001315	Caspase Recruitment
InterPro	IPR011029	DEATH-like
Protein Ontology	PR:000005041	caspase recruitment domain-containing protein 9

References

(Earliest) J:111706 Gross O, et al., Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature. 2006 Aug 10;442(7103):651-6
(Latest) J:190717 Abdullah Z, et al., RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J. 2012 Nov 5;31(21):4153-64
All references(47)