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Card9
Gene Detail
Symbol

Name
ID
Card9
caspase recruitment domain family, member 9
MGI:2685628
Synonyms
LOC332579
Feature Type
protein coding gene
Genetic Map
Chromosome 2
18.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:26352187-26360918 bp, - strand
From VEGA annotation of GRCm38

  8732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: caspase recruitment domain-containing protein 9
Gene Tree: Card9

Human
homologs
Human Homolog CARD9, caspase recruitment domain family, member 9
NCBI Gene ID 64170
neXtProt AC  NX_Q9H257
Human Synonyms  CANDF2, hCARD9
Human Chr (Location)  9q34.3; chr9:136363956-136373681 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CARD9
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for one allele of this gene display impaired immune responses to fungal infection but normal rates of bacterial clearance. However, homozygotes for a second allele display impaired bacterial clearance and impaired early innate immune responses.
 
Interactions
Card9 interacts with 31 markers (Mir101a, Mir101b, Mir103-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process defense response to Gram-positive bacterium, defense response to virus, ...
Component cytoplasm
Function CARD domain binding, protein binding, ...
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000012770 (Evidence)
Ensembl Gene ModelENSMUSG00000026928 (Evidence)
Entrez Gene332579 (Evidence)
UniGene330064
DFCITC1592767
DoTSDT.97366742
NIA Mouse Gene IndexU276900
Consensus CDS ProjectCCDS38084.1
International Mouse Knockout Project StatusCard9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012770 VEGA Gene Model | MGI Sequence Detail 8732 C57BL/6J ±  kb
transcript OTTMUST00000030553 VEGA | MGI Sequence Detail 1880 Not Applicable 
polypeptide OTTMUSP00000013722 VEGA | MGI Sequence Detail 536 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(13) UniProt(3)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
Protein Ontology PR:000005041 caspase recruitment domain-containing protein 9
References
(Earliest) J:111706 Gross O, et al., Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature. 2006 Aug 10;442(7103):651-6
(Latest) J:210238 Hung CY, et al., Interleukin-1 receptor but not Toll-like receptor 2 is essential for MyD88-dependent Th17 immunity to Coccidioides infection. Infect Immun. 2014 May;82(5):2106-14
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory