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Card9
Gene Detail
Symbol

Name
ID
Card9
caspase recruitment domain family, member 9
MGI:2685628
Synonyms
LOC332579
Feature Type
protein coding gene
Genetic Map
Chromosome 2
18.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:26352187-26360918 bp, - strand
From VEGA annotation of GRCm38

  8732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CARD9
Protein SuperFamily: caspase recruitment domain-containing protein 9
Gene Tree: Card9

Human
homologs
CARD9, caspase recruitment domain family, member 9
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64170
neXtProt AC: NX_Q9H257

Human Synonyms: CANDF2, hCARD9

Human Chr (Location): 9q34.3; chr9:136363956-136373681 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CARD9

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for one allele of this gene display impaired immune responses to fungal infection but normal rates of bacterial clearance. However, homozygotes for a second allele display impaired bacterial clearance and impaired early innate immune responses.
 
Interactions
Card9 interacts with 31 markers (Mir101a, Mir101b, Mir103-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process defense response to Gram-positive bacterium, defense response to virus, ...
Component cytoplasm
Function CARD domain binding, protein binding, ...
External Resources: FuncBase
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase card9    NEW 
Molecular
reagents
All nucleic(6) cDNA(5) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000012770 (Evidence)
Ensembl Gene Model ENSMUSG00000026928 (Evidence)
Entrez Gene 332579 (Evidence)
UniGene 330064
DFCI TC1592767
DoTS DT.97366742
NIA Mouse Gene Index U276900
Consensus CDS Project CCDS38084.1
International Mouse Phenotyping Consortium Status Card9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012770 VEGA Gene Model | MGI Sequence Detail 8732 C57BL/6J ±  kb
transcript OTTMUST00000030553 VEGA | MGI Sequence Detail 1880 Not Applicable 
polypeptide OTTMUSP00000013722 VEGA | MGI Sequence Detail 536 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(7) UniProt(2)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
Protein Ontology PR:000005041 caspase recruitment domain-containing protein 9
References
(Earliest) J:111706 Gross O, et al., Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature. 2006 Aug 10;442(7103):651-6
(Latest) J:218677 Jia XM, et al., CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity. J Exp Med. 2014 Oct 20;211(11):2307-21
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory