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Kcnk18
Gene Detail
Symbol

Name
ID
Kcnk18
potassium channel, subfamily K, member 18
MGI:2685627
Synonyms
LOC332396, Tresk, Tresk-2, Trik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
54.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:59219648-59237370 bp, + strand
From NCBI annotation of GRCm38

  17723 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133808  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNK18
Gene Tree: Kcnk18

Human
homologs
KCNK18, potassium channel, two pore domain subfamily K, member 18
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 338567
neXtProt AC: NX_Q7Z418

Human Synonyms: K2p18.1, MGR13, TRESK, TRESK2, TRESK-2, TRIK

Human Chr (Location): 10q25.3; chr10:117197489-117210299 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KCNK18

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for an ENU-induced allele exhibit altered potassium conductance and neuron electrophysiology.
 
Interactions
Kcnk18 interacts with 218 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(10)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000040901 (Evidence)
Entrez Gene 332396 (Evidence)
UniGene 329947
DFCI TC1599196
DoTS DT.101350712
NIA Mouse Gene Index U019623
Consensus CDS Project CCDS29934.1
International Mouse Phenotyping Consortium Status Kcnk18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 332396 NCBI Gene Model | MGI Sequence Detail 17723 C57BL/6J ±  kb
transcript NM_207261 RefSeq | MGI Sequence Detail 3032 C57BL/6 
polypeptide Q6VV64 UniProt | EBI | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013099 Ion transport 2
InterPro IPR003280 Two pore domain potassium channel
InterPro IPR003092 Two pore domain potassium channel, TASK family
Protein Ontology PR:000009264 potassium channel subfamily K member 18
Graphical View of Protein Domain Structure
References
(Earliest) J:90661 Czirjak G, et al., The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin. J Biol Chem. 2004 Apr 30;279(18):18550-8
(Latest) J:212722 Guo Z, et al., Over-expression of TRESK K(+) channels reduces the excitability of trigeminal ganglion nociceptors. PLoS One. 2014;9(1):e87029
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory