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Kcnk18 Gene Detail
Summary
  • Symbol
    Kcnk18
  • Name
    potassium channel, subfamily K, member 18
  • Synonyms
    LOC332396, Tresk, Tresk-2, Trik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685627
    NCBI Gene: 332396
  • Gene Overview
    MyGene.info: KCNK18
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr19:59219648-59237370 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 54.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685627
protein coding gene Chr19:59219648-59237370 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025286
protein coding gene Chr19:59732090-59747778 (+)
A/J MGP_AJ_G0025262
protein coding gene Chr19:56817121-56831775 (+)
AKR/J MGP_AKRJ_G0025231
protein coding gene Chr19:58580117-58594826 (+)
BALB/cJ MGP_BALBcJ_G0025257
protein coding gene Chr19:56882605-56897254 (+)
C3H/HeJ MGP_C3HHeJ_G0025017
protein coding gene Chr19:58837683-58854008 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025700
protein coding gene Chr19:61174913-61192656 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023112
protein coding gene Chr19:55694262-55710800 (+)
CAST/EiJ MGP_CASTEiJ_G0024482
protein coding gene Chr19:58929983-58944638 (+)
CBA/J MGP_CBAJ_G0024997
protein coding gene Chr19:64163269-64182327 (+)
DBA/2J MGP_DBA2J_G0025129
protein coding gene Chr19:56576293-56593944 (+)
FVB/NJ MGP_FVBNJ_G0025090
protein coding gene Chr19:56304335-56318993 (+)
LP/J MGP_LPJ_G0025215
protein coding gene Chr19:59609322-59623966 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025123
protein coding gene Chr19:63380208-63397926 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025758
protein coding gene Chr19:58826021-58843908 (+)
PWK/PhJ MGP_PWKPhJ_G0024230
protein coding gene Chr19:56589090-56591635 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024033
protein coding gene Chr19:57477521-57496789 (+)
WSB/EiJ MGP_WSBEiJ_G0024552
protein coding gene Chr19:58937996-58952649 (+)



Homology
more
  • Human Ortholog
    KCNK18, potassium two pore domain channel subfamily K member 18
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNK18, potassium two pore domain channel subfamily K member 18
    Orthology source: HomoloGene, HGNC
  • Synonyms
    K2p18.1, MGR13, TRESK, TRESK2, TRESK-2, TRIK
  • Links
    NCBI Gene ID: 338567
    neXtProt AC: NX_Q7Z418
    UniProt: Q7Z418

  • Chr Location
    10q25.3; chr10:117197489-117210299 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KCNK18 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit altered potassium conductance and neuron electrophysiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 332396 NCBI Gene Model | MGI Sequence Detail 17723 C57BL/6J ±  kb
    transcript NM_207261 RefSeq | MGI Sequence Detail 3032 C57BL/6  
    polypeptide Q6VV64 UniProt | EBI | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 11

      Microarray probesets 1
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:90661 Czirjak G, et al., The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin. J Biol Chem. 2004 Apr 30;279(18):18550-8
    • Latest
      J:256443 Castellanos A, et al., Pyrethroids inhibit K2P channels and activate sensory neurons: basis of insecticide-induced paraesthesias. Pain. 2017 Sep 25;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory