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Drc7 Gene Detail
Summary
  • Symbol
    Drc7
  • Name
    dynein regulatory complex subunit 7
  • Synonyms
    Ccdc135, LOC330830, SRG-L
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685616
    NCBI Gene: 330830
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95781731-95804769 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    664 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685616
 protein coding gene Chr8:95781731-95804769 (+)
129S1/SvImJ ENSMUSG00200016533
 protein coding gene Chr8:90142879-90165908 (+)
A/J ENSMUSG00195027868
 protein coding gene Chr8:90495375-90518459 (+)
AKR/J ENSMUSG00220037331
 protein coding gene Chr8:90532194-90555273 (+)
BALB/cJ ENSMUSG00180003809
 protein coding gene Chr8:90379773-90402811 (+)
C3H/HeJ ENSMUSG00175025180
 protein coding gene Chr8:90438573-90461651 (+)
C57BL/6NJ ENSMUSG00215017195
 protein coding gene Chr8:90054003-90077047 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031415
 protein coding gene Chr8:86547070-86570280 (+)
CAST/EiJ ENSTCUG00005016298
 protein coding gene Chr8:89900749-89923750 (+)
CBA/J ENSMUSG00210029846
 protein coding gene Chr8:90373665-90396672 (+)
DBA/2J ENSMUSG00185021810
 protein coding gene Chr8:96482525-96505535 (+)
FVB/NJ ENSMUSG00205011360
 protein coding gene Chr8:89467224-89490258 (+)
JF1/MsJ ENSUMUG00000041473
 protein coding gene Chr8:98834122-98857161 (+)
LP/J ENSMUSG00230028509
 protein coding gene Chr8:100136156-100159228 (+)
NOD/ShiLtJ ENSMUSG00190011765
 protein coding gene Chr8:90505328-90528325 (+)
NZO/HlLtJ ENSMUSG00225011179
 protein coding gene Chr8:103532810-103555842 (+)
PWK/PhJ ENSLUMG00010035152
 protein coding gene Chr8:90227432-90250499 (+)
SPRET/EiJ ENSMSPG00010006286
 protein coding gene Chr8:92233016-92256108 (+)
WSB/EiJ ENSIUOG00005005220
 protein coding gene Chr8:91208577-91231623 (+)



Homology
more
  • Human Ortholog
    DRC7, dynein regulatory complex subunit 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRC7, dynein regulatory complex subunit 7
  • Synonyms
    C16orf50, CCDC135, CFAP50, FAP50
  • Links
    NCBI Gene ID: 84229
    UniProt: Q8IY82

  • Chr Location
    16q21; chr16:57694793-57731805 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele are infertile with very few spermatozoa, immotile sperm, and abnormal sperm head and flagellum morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    630
  • Tissues
    3
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 330830 NCBI Gene Model | MGI Sequence Detail 23039 C57BL/6J ±  kb
    transcript NM_001042715 RefSeq | MGI Sequence Detail 2832 Not Specified  
    polypeptide Q6V3W6 UniProt | EBI | MGI Sequence Detail 876 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000032324 dynein regulatory complex subunit 7
      (term hierarchy)
    • InterPro Domains
      IPR056290 CEP76/DRC7, peptidase-like domain
      IPR033551 Dynein regulatory complex subunit 7
      IPR056292 Dynein regulatory complex subunit 7, C-terminal
      IPR056291 Dynein regulatory complex subunit 7, MORN domain
      IPR038765 Papain-like cysteine peptidase superfamily
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 1
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:113018 Ma Q, et al., Molecular cloning and characterization of SRG-L, a novel mouse gene developmentally expressed in spermatogenic cells. Mol Reprod Dev. 2006 Sep;73(9):1075-83
    • Latest
      J:373993 Ren C, et al., Core N-DRC components play a crucial role in embryonic development and postnatal organ development. Cell Death Dis. 2025 Mar 15;16(1):176
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory