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Dnaic2 Gene Detail
Summary
  • Symbol
    Dnaic2
  • Name
    dynein, axonemal, intermediate chain 2
  • Synonyms
    b2b3405Clo, C030015H18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685574
    NCBI Gene: 432611
  • Gene Overview
    MyGene.info: DNAI2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:114727408-114757889 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30482 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.19 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DNAI2, dynein axonemal intermediate chain 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNAI2, dynein axonemal intermediate chain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD9, DIC2
  • Links
    NCBI Gene ID: 64446
    neXtProt AC: NX_Q9GZS0
    UniProt: Q9GZS0

  • Chr Location
    17q25.1; chr17:74274215-74314884 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11311
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DNAI2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Dnaic2 mouse models; 1 with human DNAI2 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit situs inversus totalis and immotile respiratory cilia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003426 VEGA Gene Model | MGI Sequence Detail 30482 C57BL/6J ±  kb
    transcript OTTMUST00000007219 VEGA | MGI Sequence Detail 2874 Not Applicable  
    polypeptide OTTMUSP00000003476 VEGA | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      96 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR001680 WD40 repeat
      IPR017986 WD40-repeat-containing domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:5619078
    References
    more
    • Summaries
      All 24
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 4
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory