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Dnaic2 Gene Detail
Summary
  • Symbol
    Dnaic2
  • Name
    dynein, axonemal, intermediate chain 2
  • Synonyms
    b2b3405Clo, C030015H18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685574
    NCBI Gene: 432611
  • Gene Overview
    MyGene.info: DNAI2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:114727408-114757889 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685574
protein coding gene Chr11:114722209-114757889 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019358
protein coding gene Chr11:118658609-118696957 (+)
A/J MGP_AJ_G0019327
protein coding gene Chr11:113505220-113535247 (+)
AKR/J MGP_AKRJ_G0019295
protein coding gene Chr11:116856629-116893234 (+)
BALB/cJ MGP_BALBcJ_G0019300
protein coding gene Chr11:113920510-113953984 (+)
C3H/HeJ MGP_C3HHeJ_G0019109
protein coding gene Chr11:117208761-117243210 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019751
protein coding gene Chr11:122215725-122261582 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017374
protein coding gene Chr11:110567911-110599931 (+)
CAST/EiJ MGP_CASTEiJ_G0018663
protein coding gene Chr11:118533614-118572113 (+)
CBA/J MGP_CBAJ_G0019079
protein coding gene Chr11:127104768-127144925 (+)
DBA/2J MGP_DBA2J_G0019191
protein coding gene Chr11:112946229-112977778 (+)
FVB/NJ MGP_FVBNJ_G0019182
protein coding gene Chr11:112423244-112456159 (+)
LP/J MGP_LPJ_G0019261
protein coding gene Chr11:119068861-119103247 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019213
protein coding gene Chr11:126269208-126309633 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019788
protein coding gene Chr11:117531082-117566665 (+)
PWK/PhJ MGP_PWKPhJ_G0018428
protein coding gene Chr11:114179979-114211952 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018220
protein coding gene Chr11:117333768-117370689 (+)
WSB/EiJ MGP_WSBEiJ_G0018715
protein coding gene Chr11:117493220-117527724 (+)



Homology
more
  • Human Ortholog
    DNAI2, dynein axonemal intermediate chain 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNAI2, dynein axonemal intermediate chain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD9, DIC2
  • Links
    NCBI Gene ID: 64446
    neXtProt AC: NX_Q9GZS0
    UniProt: Q9GZS0

  • Chr Location
    17q25.1; chr17:74274215-74314884 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11311
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DNAI2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Dnaic2 mouse models; 1 with human DNAI2 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit situs inversus totalis and immotile respiratory cilia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034706 Ensembl Gene Model | MGI Sequence Detail 30482 C57BL/6J ±  kb
    transcript ENSMUST00000092469 Ensembl | MGI Sequence Detail 2799 Not Applicable  
    polypeptide ENSMUSP00000090126 Ensembl | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR001680 WD40 repeat
      IPR017986 WD40-repeat-containing domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:5619078
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 4
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory