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Shroom4 Gene Detail
Summary
  • Symbol
    Shroom4
  • Name
    shroom family member 4
  • Synonyms
    D430043L16Rik, Shrm4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685570
    NCBI Gene: 208431
Location & Maps
more
  • Sequence Map
    ChrX:6399854-6637448 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      237595 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SHROOM4, shroom family member 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SHROOM4, shroom family member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SHAP
  • Links
    NCBI Gene ID: 57477
    neXtProt AC: NX_Q9ULL8

  • Chr Location
    Xp11.22; chrX:50576993-50814139 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SHROOM4 associations

Human Disease Mouse Models
       Stocco Dos Santos X-Linked Mental Retardation Syndrome   OMIM: 300434
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016659 VEGA Gene Model | MGI Sequence Detail 237595 C57BL/6J ±  kb
transcript OTTMUST00000040329 VEGA | MGI Sequence Detail 4839 Not Applicable  
polypeptide OTTMUSP00000051223 VEGA | MGI Sequence Detail 1475 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    406 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 23
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:114885 Dietz ML, et al., Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. J Biol Chem. 2006 Jul 21;281(29):20542-54
  • Latest
    J:124995 Etournay R, et al., Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions. J Cell Sci. 2007 Aug 15;120(Pt 16):2838-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory