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Prdm11 Gene Detail
Summary
  • Symbol
    Prdm11
  • Name
    PR domain containing 11
  • Synonyms
    8030443D09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685553
    NCBI Gene: 100042784
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:92802363-92876512 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 51.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    529 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685553
protein coding gene Chr2:92795496-92876825 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026172
protein coding gene Chr2:94441811-94530953 (-)
A/J MGP_AJ_G0026133
protein coding gene Chr2:90602744-90687317 (-)
AKR/J MGP_AKRJ_G0026114
protein coding gene Chr2:93134310-93218857 (-)
BALB/cJ MGP_BALBcJ_G0026142
protein coding gene Chr2:90796076-90877870 (-)
C3H/HeJ MGP_C3HHeJ_G0025893
protein coding gene Chr2:93416460-93503248 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026593
protein coding gene Chr2:97660951-97748119 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023984
protein coding gene Chr2:87097601-87176811 (-)
CAST/EiJ MGP_CASTEiJ_G0025358
protein coding gene Chr2:93990595-94074448 (-)
CBA/J MGP_CBAJ_G0025871
protein coding gene Chr2:101061091-101146633 (-)
DBA/2J MGP_DBA2J_G0026007
protein coding gene Chr2:90214899-90296784 (-)
FVB/NJ MGP_FVBNJ_G0025970
protein coding gene Chr2:89311506-89404374 (-)
LP/J MGP_LPJ_G0026111
protein coding gene Chr2:94630507-94719401 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025996
protein coding gene Chr2:104007480-104094206 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026647
protein coding gene Chr2:93206444-93298504 (-)
PWK/PhJ MGP_PWKPhJ_G0025093
protein coding gene Chr2:89954547-90036864 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024894
protein coding gene Chr2:92782269-92862390 (-)
WSB/EiJ MGP_WSBEiJ_G0025425
protein coding gene Chr2:93826015-93911278 (-)



Homology
more
  • Human Ortholog
    PRDM11, PR/SET domain 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDM11, PR/SET domain 11
  • Synonyms
    PFM8
  • Links
    NCBI Gene ID: 56981
    neXtProt AC: NX_Q9NQV5
    UniProt: Q9NQV5

  • Chr Location
    11p11.2; chr11:45094159-45235110 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show increased cell numbers in bronchioalveolar lavages and changes in B cell, CD4+ T cell and neutrophil counts following ovalbumin airway challenge, and a small decrease in megakaryocytic progenitors and a small increase in hematopoietic progenitor cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075028 Ensembl Gene Model | MGI Sequence Detail 74150 C57BL/6J ±  kb
transcript ENSMUST00000238863 Ensembl | MGI Sequence Detail 3744 Not Applicable  
polypeptide ENSMUSP00000158933 Ensembl | MGI Sequence Detail 1172 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:3035500
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:318371 Ye A, et al., PEG3 binds to H19-ICR as a transcriptional repressor. Epigenetics. 2016 Dec;11(12):889-900

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory