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Wdtc1 Gene Detail
Summary
  • Symbol
    Wdtc1
  • Name
    WD and tetratricopeptide repeats 1
  • Synonyms
    adipose, adp, LOC230796
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685541
    NCBI Gene: 230796
Location & Maps
more
  • Sequence Map
    Chr4:133292459-133353481 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      61023 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    WDTC1, WD and tetratricopeptide repeats 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WDTC1, WD and tetratricopeptide repeats 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADP, DCAF9
  • Links
    NCBI Gene ID: 23038
    neXtProt AC: NX_Q8N5D0

  • Chr Location
    1p36.11; chr1:27234516-27308633 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8997
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: WDTC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    87
  • Chemically induced (other)
    2
  • Gene trapped
    79
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    2
  • Genomic Mutations
    4 involving Wdtc1
  • Incidental Mutations
Mice heterozygous for a gene trapped allele are obese and insulin resistant with significantly elevated plasma insulin and leptin levels. Although a number of adult homozygotes are also described as obese, the majority of homozygotes die in utero thus precluding statistically significant analyses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011148 VEGA Gene Model | MGI Sequence Detail 61023 C57BL/6J ±  kb
transcript OTTMUST00000026111 VEGA | MGI Sequence Detail 4191 Not Applicable  
polypeptide OTTMUSP00000011951 VEGA | MGI Sequence Detail 677 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    728 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000031217 WD and tetratricopeptide repeats protein 1
  • InterPro Domains
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 16
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:218473 Wu Y, et al., Adipose induces myoblast differentiation and mediates TNFalpha-regulated myogenesis. Biochim Biophys Acta. 2014 Nov;1839(11):1183-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory