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Arhgef40 Gene Detail
Summary
  • Symbol
    Arhgef40
  • Name
    Rho guanine nucleotide exchange factor (GEF) 40
  • Synonyms
    E130112L23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685515
    NCBI Gene: 268739
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51984719-52006251 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 26.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685515
protein coding gene Chr14:51984681-52006251 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021286
protein coding gene Chr14:45995358-46016540 (+)
A/J MGP_AJ_G0021243
protein coding gene Chr14:44802889-44827349 (+)
AKR/J MGP_AKRJ_G0021219
protein coding gene Chr14:46419000-46440235 (+)
BALB/cJ MGP_BALBcJ_G0021247
protein coding gene Chr14:44911204-44932428 (+)
C3H/HeJ MGP_C3HHeJ_G0021027
protein coding gene Chr14:46231232-46252412 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021686
protein coding gene Chr14:48028574-48053338 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019231
protein coding gene Chr14:43998832-44020421 (+)
CAST/EiJ MGP_CASTEiJ_G0020546
protein coding gene Chr14:43203522-43225709 (+)
CBA/J MGP_CBAJ_G0020994
protein coding gene Chr14:49495793-49518754 (+)
DBA/2J MGP_DBA2J_G0021115
protein coding gene Chr14:44568918-44590067 (+)
FVB/NJ MGP_FVBNJ_G0021098
protein coding gene Chr14:44158960-44180098 (+)
LP/J MGP_LPJ_G0021190
protein coding gene Chr14:46598848-46620039 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021121
protein coding gene Chr14:48948620-48969877 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021713
protein coding gene Chr14:45804938-45826163 (+)
PWK/PhJ MGP_PWKPhJ_G0020295
protein coding gene Chr14:41322696-41344300 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020122
protein coding gene Chr14:41830174-41862639 (+)
WSB/EiJ MGP_WSBEiJ_G0020599
protein coding gene Chr14:46125522-46147695 (+)



Homology
more
  • Human Ortholog
    ARHGEF40, Rho guanine nucleotide exchange factor 40
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ARHGEF40, Rho guanine nucleotide exchange factor 40
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SOLO
  • Links
    NCBI Gene ID: 55701
    neXtProt AC: NX_Q8TER5
    UniProt: Q8TER5

  • Chr Location
    14q11.2; chr14:21061276-21090248 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004562 Ensembl Gene Model | MGI Sequence Detail 21533 C57BL/6J ±  kb
transcript ENSMUST00000182760 Ensembl | MGI Sequence Detail 5130 Not Applicable  
polypeptide ENSMUSP00000138125 Ensembl | MGI Sequence Detail 1526 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 6
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory