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Slc9c1 Gene Detail
Summary
  • Symbol
    Slc9c1
  • Name
    solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
  • Synonyms
    LOC208169, Slc9a10, spermNHE
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685456
    NCBI Gene: 208169
  • Gene Overview
    MyGene.info: SLC9C1
Location & Maps
more
  • Sequence Map
    Chr16:45535309-45607001 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71693 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 29.53 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLC9C1, solute carrier family 9 member C1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    SLC9C1, solute carrier family 9 member C1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NHE, NHE-10, SLC9A10, sperm-NHE
  • Links
    NCBI Gene ID: 285335
    neXtProt AC: NX_Q4G0N8

  • Chr Location
    3q13.2; chr3:112140898-112362986 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Incidental Mutations
    APF , CvDC
Homozygous null mice display male infertility and asthenozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034157 VEGA Gene Model | MGI Sequence Detail 71693 C57BL/6J ±  kb
transcript OTTMUST00000086549 VEGA | MGI Sequence Detail 3836 Not Applicable  
polypeptide OTTMUSP00000046874 VEGA | MGI Sequence Detail 1175 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    816 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015211 sodium/hydrogen exchanger 10
  • InterPro Domains
    IPR006153 Cation/H+ exchanger
    IPR018422 Cation/H+ exchanger, CPA1 family
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding-like
    IPR014710 RmlC-like jelly roll fold
    IPR028483 Sodium/hydrogen exchanger 10
    IPR027359 Voltage-dependent channel, four helix bundle domain
Molecular
Reagents
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  • All nucleic 3
    cDNA 2
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:87248 Wang D, et al., A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. Nat Cell Biol. 2003 Dec;5(12):1117-22
  • Latest
    J:219572 Jansen V, et al., Controlling fertilization and cAMP signaling in sperm by optogenetics. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory