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Rimbp3 Gene Detail
Summary
  • Symbol
    Rimbp3
  • Name
    RIMS binding protein 3
  • Synonyms
    LOC239731, LOC385766, RIM-BP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685449
    NCBI Gene: 239731
Location & Maps
more
  • Sequence Map
    Chr16:17208135-17213921 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5787 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.67 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RIMBP3, RIMS binding protein 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    RIMBP3, RIMS binding protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RIM-BP3, RIM-BP3.1, RIMBP3.1, RIMBP3A, RIM-BP3.A
  • Links
    NCBI Gene ID: 85376
    neXtProt AC: NX_Q9UFD9

  • Chr Location
    chr22:18606124-18611919 (-)  GRCh38.p2

  • Human Ortholog
    RIMBP3B, RIMS binding protein 3B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RIM-BP3.2, RIMBP3.2, RIM-BP3.B
  • Links
    NCBI Gene ID: 440804
    neXtProt AC: NX_A6NNM3

  • Chr Location
    22q11.21; chr22:21383751-21389169 (+)  GRCh38.p2

  • Human Ortholog
    RIMBP3C, RIMS binding protein 3C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RIM-BP3.3, RIMBP3.3
  • Links
    NCBI Gene ID: 150221
    neXtProt AC: NX_A6NJZ7

  • Chr Location
    22q11.21; chr22:21545666-21551461 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null mutation display infertility with impaired spermiogenesis and defects in sperm head and flagellum morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024840 VEGA Gene Model | MGI Sequence Detail 5787 C57BL/6J ±  kb
transcript OTTMUST00000061191 VEGA | MGI Sequence Detail 5787 Not Applicable  
polypeptide OTTMUSP00000029961 VEGA | MGI Sequence Detail 1606 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    17 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 2
Other
Accession IDs
less
MGI:2686605
References
more
  • Summaries
    All 20
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:144218 Zhou J, et al., RIM-BP3 is a manchette-associated protein essential for spermiogenesis. Development. 2009 Feb;136(3):373-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory