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Nuggc Gene Detail
Summary
  • Symbol
    Nuggc
  • Name
    nuclear GTPase, germinal center associated
  • Synonyms
    Gm600, LOC239151, SLIP-GC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685446
    NCBI Gene: 100503545
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr14:65598546-65648531 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    490 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685446
protein coding gene Chr14:65593499-65648531 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021482
protein coding gene Chr14:60212235-60268323 (+)
A/J MGP_AJ_G0021441
protein coding gene Chr14:58817808-58868492 (+)
AKR/J MGP_AKRJ_G0021417
protein coding gene Chr14:60858849-60911007 (+)
BALB/cJ MGP_BALBcJ_G0021447
protein coding gene Chr14:58753605-58804971 (+)
C3H/HeJ MGP_C3HHeJ_G0021224
protein coding gene Chr14:60497882-60551266 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021886
protein coding gene Chr14:62989430-63046348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019426
protein coding gene Chr14:56748395-56799478 (+)
CAST/EiJ MGP_CASTEiJ_G0020741
protein coding gene Chr14:56984319-57037878 (+)
CBA/J MGP_CBAJ_G0021191
protein coding gene Chr14:64893111-64952000 (+)
DBA/2J MGP_DBA2J_G0021314
protein coding gene Chr14:58466047-58516988 (+)
FVB/NJ MGP_FVBNJ_G0021293
protein coding gene Chr14:57866027-57916596 (+)
LP/J MGP_LPJ_G0021389
protein coding gene Chr14:61246910-61304902 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021322
protein coding gene Chr14:63995133-64053048 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021909
protein coding gene Chr14:60038812-60093488 (+)
PWK/PhJ MGP_PWKPhJ_G0020485
protein coding gene Chr14:55177199-55229829 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020318
protein coding gene Chr14:56003504-56066643 (+)
WSB/EiJ MGP_WSBEiJ_G0020794
protein coding gene Chr14:60347686-60401273 (+)



Homology
more
  • Human Ortholog
    NUGGC, nuclear GTPase, germinal center associated
  • Vertebrate Orthologs
    12
  • Human Ortholog
    NUGGC, nuclear GTPase, germinal center associated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C8orf80, HMFN0672, SLIP-GC
  • Links
    NCBI Gene ID: 389643
    neXtProt AC: NX_Q68CJ6
    UniProt: Q68CJ6

  • Chr Location
    8p21.1; chr8:28021964-28084068 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    5
  • Genomic Mutations
    1 involving Nuggc
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit increased somatic mutation frequency immunoglobulin and non-immunoglobulin loci in B cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061356 Ensembl Gene Model | MGI Sequence Detail 49986 C57BL/6J ±  kb
transcript ENSMUST00000079469 Ensembl | MGI Sequence Detail 2567 Not Applicable  
polypeptide ENSMUSP00000078434 Ensembl | MGI Sequence Detail 812 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 19
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:190402 Richter K, et al., Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. J Biol Chem. 2012 Sep 14;287(38):31856-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory