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Asap2 Gene Detail
Summary
  • Symbol
    Asap2
  • Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
  • Synonyms
    6530401G17Rik, Ddef2, LOC385250
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685438
    NCBI Gene: 211914
  • Gene Overview
    MyGene.info: ASAP2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:21111713-21270171 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2150 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685438
protein coding gene Chr12:21111713-21270171 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019621
protein coding gene Chr12:18718109-18820014 (+)
A/J MGP_AJ_G0019588
protein coding gene Chr12:18014374-18113655 (+)
AKR/J MGP_AKRJ_G0019559
protein coding gene Chr12:18840633-18947448 (+)
BALB/cJ MGP_BALBcJ_G0019565
protein coding gene Chr12:18391940-18488448 (+)
C3H/HeJ MGP_C3HHeJ_G0019369
protein coding gene Chr12:18733078-18838883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020013
protein coding gene Chr12:19408583-19516323 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017638
protein coding gene Chr12:17613815-17712723 (+)
CAST/EiJ MGP_CASTEiJ_G0018924
protein coding gene Chr12:15898488-16113423 (+)
CBA/J MGP_CBAJ_G0019341
protein coding gene Chr12:20140282-20252814 (+)
DBA/2J MGP_DBA2J_G0019454
protein coding gene Chr12:18046023-18146369 (+)
FVB/NJ MGP_FVBNJ_G0019445
protein coding gene Chr12:17947061-18047945 (+)
LP/J MGP_LPJ_G0019524
protein coding gene Chr12:18816841-18921254 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019480
protein coding gene Chr12:19971283-20075712 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020052
protein coding gene Chr12:18421793-18523319 (+)
PWK/PhJ MGP_PWKPhJ_G0018690
protein coding gene Chr12:15313546-15415831 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018479
protein coding gene Chr12:15708743-15810406 (+)
WSB/EiJ MGP_WSBEiJ_G0018975
protein coding gene Chr12:18602208-18707635 (+)



Homology
more
  • Human Ortholog
    ASAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ASAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1
  • Links
    NCBI Gene ID: 8853
    neXtProt AC: NX_O43150
    UniProt: O43150

  • Chr Location
    2p25; chr2:9206765-9405683 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2888
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ASAP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 211914 NCBI Gene Model | MGI Sequence Detail 158459 C57BL/6J ±  kb
transcript NM_001135192 RefSeq | MGI Sequence Detail 5686 C57BL/6  
polypeptide Q7SIG6 UniProt | EBI | MGI Sequence Detail 958 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923478, MGI:2686369
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:251423 Zhao J, et al., ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity. Biochem Biophys Res Commun. 2017 May 13;486(4):865-871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory