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Carmil2 Gene Detail
Summary
  • Symbol
    Carmil2
  • Name
    capping protein regulator and myosin 1 linker 2
  • Synonyms
    D130029J02Rik, Rltpr
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685431
    NCBI Gene: 234695
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105686274-105698187 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685431
protein coding gene Chr8:105686010-105698195 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034053
protein coding gene Chr8:107989053-108000982 (+)
A/J MGP_AJ_G0034034
protein coding gene Chr8:103672487-103684537 (+)
AKR/J MGP_AKRJ_G0033960
protein coding gene Chr8:106673454-106685379 (+)
BALB/cJ MGP_BALBcJ_G0034027
protein coding gene Chr8:103863010-103874939 (+)
C3H/HeJ MGP_C3HHeJ_G0033739
protein coding gene Chr8:107414272-107426205 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034547
protein coding gene Chr8:111956980-111968909 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031489
protein coding gene Chr8:96806947-96822580 (+)
CAST/EiJ MGP_CASTEiJ_G0033065
protein coding gene Chr8:106913926-106926009 (+)
CBA/J MGP_CBAJ_G0033712
protein coding gene Chr8:115550435-115562360 (+)
DBA/2J MGP_DBA2J_G0033867
protein coding gene Chr8:103019894-103031823 (+)
FVB/NJ MGP_FVBNJ_G0033813
protein coding gene Chr8:101946232-101960640 (+)
LP/J MGP_LPJ_G0033958
protein coding gene Chr8:108196279-108208208 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033856
protein coding gene Chr8:118746946-118758879 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034565
protein coding gene Chr8:106637400-106649329 (+)
PWK/PhJ MGP_PWKPhJ_G0032766
protein coding gene Chr8:102410292-102422439 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032607
protein coding gene Chr8:105317590-105334471 (+)
WSB/EiJ MGP_WSBEiJ_G0033181
protein coding gene Chr8:107304511-107318967 (+)



Homology
more
  • Human Ortholog
    CARMIL2, capping protein regulator and myosin 1 linker 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CARMIL2, capping protein regulator and myosin 1 linker 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CARMIL2b, IMD58, LRRC16C, RLTPR
  • Links
    NCBI Gene ID: 146206
    neXtProt AC: NX_Q6F5E8
    UniProt: Q6F5E8

  • Chr Location
    16q22.1; chr16:67645004-67657569 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out or ENU-induced allele exhibit decreased regulatory T cells and reduced proliferative and IL2-secretion response to anti-CD3 and anti-CD28 antibodies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050357 Ensembl Gene Model | MGI Sequence Detail 11914 C57BL/6J ±  kb
transcript ENSMUST00000213019 Ensembl | MGI Sequence Detail 4194 Not Applicable  
polypeptide ENSMUSP00000148422 Ensembl | MGI Sequence Detail 1397 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 2
References
more
  • Summaries
    All 24
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:237261 Roncagalli R, et al., The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med. 2016 Oct 17;213(11):2437-2457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory