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Ciroz Gene Detail
Summary
  • Symbol
    Ciroz
  • Name
    ciliated left-right organizer protein containing ZP-N domains
  • Synonyms
    b2b1167Clo, Gm572, LOC230909
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685418
    NCBI Gene: 230909
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148727774-148760753 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    439 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685418
 protein coding gene Chr4:148727774-148761562 (+)
129S1/SvImJ ENSMUSG00200041879
 protein coding gene Chr4:139766944-139795443 (+)
A/J ENSMUSG00195030354
 protein coding gene Chr4:141423607-141452039 (+)
AKR/J ENSMUSG00220043253
 protein coding gene Chr4:141010509-141039010 (+)
BALB/cJ ENSMUSG00180040216
 protein coding gene Chr4:139106253-139134686 (+)
C3H/HeJ ENSMUSG00175037162
 protein coding gene Chr4:142390952-142419450 (+)
C57BL/6NJ ENSMUSG00215049256
 protein coding gene Chr4:141230001-141258257 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026806
 protein coding gene Chr4:138495558-138528378 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210025273
 protein coding gene Chr4:141042672-141071162 (+)
DBA/2J ENSMUSG00185014843
 protein coding gene Chr4:144603470-144632383 (+)
FVB/NJ ENSMUSG00205032698
 protein coding gene Chr4:139499548-139527796 (+)
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190026785
 protein coding gene Chr4:140710770-140739311 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CIROZ, ciliated left-right organizer protein containing ZP-N domains
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIROZ, ciliated left-right organizer protein containing ZP-N domains
  • Synonyms
    C1orf127, HTX14
  • Links
    NCBI Gene ID: 148345
    UniProt: Q8N9H9

  • Chr Location
    1p36.22; chr1:10946471-10982076 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with Ciroz mouse models; 1 with human CIROZ associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    22 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele show cardiovascular defects including double outlet right ventricle, dextrocardia and atrioventricular septal defects, heterotaxia with situs inversus totalis and right pulmonary isomerism, spleen hypoplasia, mid-line liver, and immotile respiratory cilia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070577 Ensembl Gene Model | MGI Sequence Detail 32980 C57BL/6J ±  kb
    transcript ENSMUST00000250014 Ensembl | MGI Sequence Detail 2402 Not Applicable  
    polypeptide ENSMUSP00000160098 Ensembl | MGI Sequence Detail 786 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR027956 CIROZ
      IPR049521 CIROZ, beta domain
      IPR054554 Zona pellucida sperm-binding protein 1/4, Ig-like domain
    Molecular
    Reagents
    less

    • Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:5431486, MGI:8161914
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:363359 Szenker-Ravi E, et al., CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans. Am J Hum Genet. 2024 Dec 27;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory