About   Help   FAQ
Kalrn Gene Detail
Summary
  • Symbol
    Kalrn
  • Name
    kalirin, RhoGEF kinase
  • Synonyms
    2210407G14Rik, E530005C20Rik, Hapip, LOC224126
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685385
    NCBI Gene: 545156
  • Gene Overview
    MyGene.info: KALRN
Location & Maps
more
  • Sequence Map
    Chr16:33974258-34573532 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      599275 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 24.27 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KALRN, kalirin, RhoGEF kinase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KALRN, kalirin, RhoGEF kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD
  • Links
    NCBI Gene ID: 8997
    neXtProt AC: NX_O60229

  • Chr Location
    3q21.2; chr3:124033339-124726325 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KALRN associations

Human Disease Mouse Models
       Coronary Heart Disease, Susceptibility to, 5   OMIM: 608901
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 4 alleles in 6 genetic backgrounds
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele specific for isoform 7 exhibit decreased anxiety-related behavior, contextual conditioning, and synapse formation. Mice homozygous for another knock-out allele exhibit impaired AMPA-mediated synaptic currents and abnormal behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017795 VEGA Gene Model | MGI Sequence Detail 599275 C57BL/6J ±  kb
transcript OTTMUST00000043072 VEGA | MGI Sequence Detail 8940 Not Applicable  
polypeptide OTTMUSP00000019365 VEGA | MGI Sequence Detail 2964 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    4221 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 6
Other
Accession IDs
less
MGI:1919628, MGI:2146601, MGI:2443174
References
more
  • Summaries
    All 46
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222722 Lu J, et al., A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses. Nat Commun. 2015;6:6820

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory