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Kalrn Gene Detail
Summary
  • Symbol
    Kalrn
  • Name
    kalirin, RhoGEF kinase
  • Synonyms
    2210407G14Rik, E530005C20Rik, Hapip, LOC224126
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685385
    NCBI Gene: 545156
  • Gene Overview
    MyGene.info: KALRN
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:33969073-34573291 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 24.27 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4236 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685385
protein coding gene Chr16:33969073-34573532 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022761
protein coding gene Chr16:32218567-32854571 (-)
A/J MGP_AJ_G0022726
protein coding gene Chr16:30663833-31255471 (-)
AKR/J MGP_AKRJ_G0022699
protein coding gene Chr16:31746948-32353745 (-)
BALB/cJ MGP_BALBcJ_G0022728
protein coding gene Chr16:30781688-31378329 (-)
C3H/HeJ MGP_C3HHeJ_G0022493
protein coding gene Chr16:31874142-32493013 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023177
protein coding gene Chr16:32928635-33553689 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020695
protein coding gene Chr16:31007810-31609905 (-)
CAST/EiJ MGP_CASTEiJ_G0022021
protein coding gene Chr16:32060095-32689659 (-)
CBA/J MGP_CBAJ_G0022463
protein coding gene Chr16:34265233-34928045 (-)
DBA/2J MGP_DBA2J_G0022596
protein coding gene Chr16:30487203-31090114 (-)
FVB/NJ MGP_FVBNJ_G0022571
protein coding gene Chr16:30480248-31077738 (-)
LP/J MGP_LPJ_G0022663
protein coding gene Chr16:31940047-32555385 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022590
protein coding gene Chr16:33608263-34247534 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023189
protein coding gene Chr16:31759670-32381016 (-)
PWK/PhJ MGP_PWKPhJ_G0021762
protein coding gene Chr16:30867231-31470243 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021591
protein coding gene Chr16:31548305-32172979 (-)
WSB/EiJ MGP_WSBEiJ_G0022065
protein coding gene Chr16:31720220-32339748 (-)



Homology
more
  • Human Ortholog
    KALRN, kalirin RhoGEF kinase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KALRN, kalirin RhoGEF kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD
  • Links
    NCBI Gene ID: 8997
    neXtProt AC: NX_O60229
    UniProt: O60229

  • Chr Location
    3q21.1-q21.2; chr3:124033341-124726325 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KALRN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 4 alleles in 6 genetic backgrounds
    2 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele specific for isoform 7 exhibit decreased anxiety-related behavior, contextual conditioning, and synapse formation. Mice homozygous for another knock-out allele exhibit impaired AMPA-mediated synaptic currents and abnormal behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 545156 NCBI Gene Model | MGI Sequence Detail 604219 C57BL/6J ±  kb
transcript NM_177357 RefSeq | MGI Sequence Detail 15439 C57BL/6  
polypeptide A2CG49 UniProt | EBI | MGI Sequence Detail 2964 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 22
    cDNA 22

    Microarray probesets 6
Other
Accession IDs
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MGI:1919628, MGI:2146601, MGI:2443174
References
more
  • Summaries
    All 52
    Gene Ontology 11
    Phenotypes 21
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:263818 McClory H, et al., The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival. Sci Rep. 2018 May 22;8(1):8000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory