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Tmem196 Gene Detail
Summary
  • Symbol
    Tmem196
  • Name
    transmembrane protein 196
  • Synonyms
    LOC217951
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685374
    NCBI Gene: 217951
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:119909557-119984981 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 63.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    344 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685374
protein coding gene Chr12:119909422-119984981 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020192
protein coding gene Chr12:122946925-123014717 (+)
A/J MGP_AJ_G0020148
protein coding gene Chr12:118451588-118515983 (+)
AKR/J MGP_AKRJ_G0020123
protein coding gene Chr12:122012295-122081547 (+)
BALB/cJ MGP_BALBcJ_G0020131
protein coding gene Chr12:118863169-118928479 (+)
C3H/HeJ MGP_C3HHeJ_G0019935
protein coding gene Chr12:122323341-122396827 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020578
protein coding gene Chr12:126794849-126866073 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018190
protein coding gene Chr12:114654675-114722794 (+)
CAST/EiJ MGP_CASTEiJ_G0019475
protein coding gene Chr12:116124808-116201996 (+)
CBA/J MGP_CBAJ_G0019902
protein coding gene Chr12:131835203-131945112 (+)
DBA/2J MGP_DBA2J_G0020019
protein coding gene Chr12:117841441-117907960 (+)
FVB/NJ MGP_FVBNJ_G0020004
protein coding gene Chr12:116437866-116510647 (+)
LP/J MGP_LPJ_G0020093
protein coding gene Chr12:122916417-122991322 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020040
protein coding gene Chr12:135139779-135235950 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020607
protein coding gene Chr12:121169788-121234252 (+)
PWK/PhJ MGP_PWKPhJ_G0019237
protein coding gene Chr12:112547268-112614930 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019042
protein coding gene Chr12:114043216-114107947 (+)
WSB/EiJ MGP_WSBEiJ_G0019533
protein coding gene Chr12:122130450-122206993 (+)



Homology
more
  • Human Ortholog
    TMEM196, transmembrane protein 196
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM196, transmembrane protein 196
  • Links
    NCBI Gene ID: 256130
    neXtProt AC: NX_Q5HYL7
    UniProt: Q5HYL7

  • Chr Location
    7p21.1; chr7:19719315-19773617 (-)  GRCh38

Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048004 Ensembl Gene Model | MGI Sequence Detail 75425 C57BL/6J ±  kb
transcript ENSMUST00000183694 Ensembl | MGI Sequence Detail 845 Not Applicable  
polypeptide ENSMUSP00000138921 Ensembl | MGI Sequence Detail 182 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR037661 Transmembrane protein 196
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 74
    Developmental Gene Expression 1
    Diseases 4
    Gene Ontology 2
    Phenotypes 58
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:343551 Chen J, et al., TMEM196 inhibits lung cancer metastasis by regulating the Wnt/beta-catenin signaling pathway. J Cancer Res Clin Oncol. 2023 Feb;149(2):653-667

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory