About   Help   FAQ
Fat2 Gene Detail
Summary
  • Symbol
    Fat2
  • Name
    FAT atypical cadherin 2
  • Synonyms
    EMI2, Fath2, LOC245827, mKIAA0811
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685369
    NCBI Gene: 245827
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:55141435-55227390 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 32.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    387 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685369
 protein coding gene Chr11:55141435-55228331 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018329
 protein coding gene Chr11:54760396-54828686 (-)
A/J MGP_AJ_G0018298
 protein coding gene Chr11:52722906-52792237 (-)
AKR/J MGP_AKRJ_G0018267
 protein coding gene Chr11:54448190-54514002 (-)
BALB/cJ MGP_BALBcJ_G0018269
 protein coding gene Chr11:53059691-53123038 (-)
C3H/HeJ MGP_C3HHeJ_G0018080
 protein coding gene Chr11:54385892-54453307 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018721
 protein coding gene Chr11:56419499-56495104 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016371
 protein coding gene Chr11:50152377-50238458 (-)
CAST/EiJ MGP_CASTEiJ_G0017645
 protein coding gene Chr11:54429105-54493419 (-)
CBA/J MGP_CBAJ_G0018055
 protein coding gene Chr11:59114508-59183835 (-)
DBA/2J MGP_DBA2J_G0018164
 protein coding gene Chr11:52416031-52480277 (-)
FVB/NJ MGP_FVBNJ_G0018156
 protein coding gene Chr11:52081617-52146509 (-)
LP/J MGP_LPJ_G0018239
 protein coding gene Chr11:55219894-55296930 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018182
 protein coding gene Chr11:60305901-60370266 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018763
 protein coding gene Chr11:54463346-54532960 (-)
PWK/PhJ MGP_PWKPhJ_G0017418
 protein coding gene Chr11:52980924-53068663 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017213
 protein coding gene Chr11:54261214-54354735 (-)
WSB/EiJ MGP_WSBEiJ_G0017693
 protein coding gene Chr11:54105558-54201677 (-)



Homology
more
  • Human Ortholog
    FAT2, FAT atypical cadherin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAT2, FAT atypical cadherin 2
  • Synonyms
    CDHF8, CDHR9, HFAT2, MEGF1, SCA45
  • Links
    NCBI Gene ID: 2196
    neXtProt AC: NX_Q9NYQ8
    UniProt: Q9NYQ8

  • Chr Location
    5q33.1; chr5:151504092-151594819 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FAT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Mice homozygous for a knock-out allele are healthy, fertile and overtly normal, with no apparent defects in the development of red blood cells or platelets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    896
  • Tissues
    37
  • cDNA Data
    8
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055333 Ensembl Gene Model | MGI Sequence Detail 85956 C57BL/6J ±  kb
transcript ENSMUST00000108864 Ensembl | MGI Sequence Detail 14423 Not Applicable  
polypeptide ENSMUSP00000104492 Ensembl | MGI Sequence Detail 4351 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 8
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 35
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:314906 Khang R, et al., Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Sci Rep. 2021 Nov 23;11(1):22745
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory