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Hspb6 Gene Detail
Summary
  • Symbol
    Hspb6
  • Name
    heat shock protein, alpha-crystallin-related, B6
  • Synonyms
    Hsp20
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685325
    NCBI Gene: 243912
  • Gene Overview
    MyGene.info: HSPB6
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30552556-30555439 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 18.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685325
protein coding gene Chr7:30552178-30555443 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032026
protein coding gene Chr7:29557208-29560478 (+)
A/J MGP_AJ_G0032003
protein coding gene Chr7:28757123-28760373 (+)
AKR/J MGP_AKRJ_G0031936
protein coding gene Chr7:29488841-29492093 (+)
BALB/cJ MGP_BALBcJ_G0032010
protein coding gene Chr7:28938630-28941880 (+)
C3H/HeJ MGP_C3HHeJ_G0031729
protein coding gene Chr7:29945039-29948307 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032476
protein coding gene Chr7:30515060-30518328 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029526
protein coding gene Chr7:29784387-29787698 (+)
CAST/EiJ MGP_CASTEiJ_G0031063
protein coding gene Chr7:23200512-23203767 (+)
CBA/J MGP_CBAJ_G0031695
protein coding gene Chr7:31968687-31971946 (+)
DBA/2J MGP_DBA2J_G0031847
protein coding gene Chr7:28486005-28489260 (+)
FVB/NJ MGP_FVBNJ_G0031804
protein coding gene Chr7:28616723-28620447 (+)
LP/J MGP_LPJ_G0031928
protein coding gene Chr7:29867137-29870390 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031840
protein coding gene Chr7:31210158-31213413 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032504
protein coding gene Chr7:28998270-29001521 (+)
PWK/PhJ MGP_PWKPhJ_G0030789
protein coding gene Chr7:23522139-23525390 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030622
protein coding gene Chr7:20007655-20010908 (+)
WSB/EiJ MGP_WSBEiJ_G0031173
protein coding gene Chr7:29384501-29387770 (+)



Homology
more
  • Human Ortholog
    HSPB6, heat shock protein family B (small) member 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HSPB6, heat shock protein family B (small) member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL55, Hsp20, PPP1R91
  • Links
    NCBI Gene ID: 126393
    neXtProt AC: NX_O14558
    UniProt: O14558

  • Chr Location
    19q13.12; chr19:35754566-35757029 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 243912 NCBI Gene Model | MGI Sequence Detail 2884 C57BL/6J ±  kb
transcript NM_001364179 RefSeq | MGI Sequence Detail 1637 C57BL/6  
polypeptide Q5EBG6 UniProt | EBI | MGI Sequence Detail 162 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 3
Other
Accession IDs
less
MGI:3035329
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:185698 Qian J, et al., Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling. Circ Res. 2011 Jun 10;108(12):1429-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory