Ffar3
Gene Detail

Symbol Name ID

Ffar3 free fatty acid receptor 3 MGI:2685324

Synonyms

Gpr41, LOC233080

Feature Type

protein coding gene

Genetic Map

Chromosome 7

19.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:30854330-30856178 bp, - strand From NCBI annotation of GRCm38   1849 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:82482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 6 zebrafish

Protein SuperFamily: free fatty acid receptor
Gene Tree: Ffar3

Human homologs

Human Homolog		FFAR3, free fatty acid receptor 3
NCBI Gene ID		2865
neXtProt AC		NX_O14843
Human Synonyms		FFA3R, GPR41
Human Chr (Location)		19q13.1; chr19:35849488-35851391 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null allele colonized with a model fermentative community are lean and exhibit decreased weight gain, increased intestinal transit rate, and reduced caloric extraction.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	G-protein coupled receptor signaling pathway, signal transduction
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, lipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (23)    Tissues (19)    Images (8)
Theiler Stages: 21, 23, 28

Assay Type	Results
RNA in situ	6
RT-PCR	17

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) Genomic(1) cDNA(3) Primer pair(1) Other(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000019429 (Evidence)
Entrez Gene	233080 (Evidence)
UniGene	291167
DoTS	DT.94280557
Consensus CDS Project	CCDS21112.1
International Mouse Knockout Project Status	Ffar3

Sequences

Length	Strain/Species
genomic	233080	NCBI Gene Model | MGI Sequence Detail	1849	C57BL/6J
transcript	NM_001033316	RefSeq | MGI Sequence Detail	1625	C57BL/6
polypeptide	Q3UFD7	UniProt | EBI | MGI Sequence Detail	319	Not Applicable

All sequences(12) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(16 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR013312	GPR40-related receptor
Protein Ontology	PR:000001584	free fatty acid receptor 3

Graphical View of Protein Domain Structure

References

(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:191508 Tolhurst G, et al., Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes. 2012 Feb;61(2):364-71
All references(24)