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Garem2 Gene Detail
Summary
  • Symbol
    Garem2
  • Name
    GRB2 associated regulator of MAPK1 subtype 2
  • Synonyms
    Fam59b, Gareml, LOC242915
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685290
    NCBI Gene: 242915
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:30105196-30118380 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 15.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685290
protein coding gene Chr5:30105161-30118380 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029383
protein coding gene Chr5:28088732-28101868 (+)
A/J MGP_AJ_G0029349
protein coding gene Chr5:27149796-27163053 (+)
AKR/J MGP_AKRJ_G0029300
protein coding gene Chr5:28234663-28247799 (+)
BALB/cJ MGP_BALBcJ_G0029360
protein coding gene Chr5:27679548-27692809 (+)
C3H/HeJ MGP_C3HHeJ_G0029081
protein coding gene Chr5:28264871-28278112 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029813
protein coding gene Chr5:29805433-29818679 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027051
protein coding gene Chr5:24670763-24683973 (+)
CAST/EiJ MGP_CASTEiJ_G0028492
protein coding gene Chr5:27368448-27381642 (+)
CBA/J MGP_CBAJ_G0029049
protein coding gene Chr5:30356448-30369703 (+)
DBA/2J MGP_DBA2J_G0029198
protein coding gene Chr5:27355077-27368340 (+)
FVB/NJ MGP_FVBNJ_G0029156
protein coding gene Chr5:26756122-26770782 (+)
LP/J MGP_LPJ_G0029283
protein coding gene Chr5:28535898-28549034 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029185
protein coding gene Chr5:31306878-31320102 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029847
protein coding gene Chr5:27797974-27812198 (+)
PWK/PhJ MGP_PWKPhJ_G0028216
protein coding gene Chr5:26464741-26478079 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028047
protein coding gene Chr5:27142222-27155471 (+)
WSB/EiJ MGP_WSBEiJ_G0028572
protein coding gene Chr5:27874775-27888885 (+)



Homology
more
  • Human Ortholog
    GAREM2, GRB2 associated regulator of MAPK1 subtype 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GAREM2, GRB2 associated regulator of MAPK1 subtype 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAM59B, GAREML
  • Links
    NCBI Gene ID: 150946
    neXtProt AC: NX_Q75VX8
    UniProt: Q75VX8

  • Chr Location
    2p23.3; chr2:26173091-26202405 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 19063
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GAREM2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    6 involving Garem2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 242915 NCBI Gene Model | MGI Sequence Detail 13185 C57BL/6J ±  kb
transcript NM_001167879 RefSeq | MGI Sequence Detail 3832 C57BL/6  
polypeptide Q6PAJ3 UniProt | EBI | MGI Sequence Detail 880 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Diseases 1
    Phenotypes 23
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:287781 Nishino T, et al., Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain. Mol Brain. 2019 Nov 12;12(1):94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory