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Nxf3 Gene Detail
Summary
  • Symbol
    Nxf3
  • Name
    nuclear RNA export factor 3
  • Synonyms
    LOC245610
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685230
    NCBI Gene: 245610
Location & Maps
more
  • Sequence Map
    ChrX:136072099-136085255 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13157 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 57.38 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NXF3, nuclear RNA export factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NXF3, nuclear RNA export factor 3
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 56000
    neXtProt AC: NX_Q9H4D5

  • Chr Location
    Xq22; chrX:103075821-103093094 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    3 phenotype references
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Genomic Mutations
    2 involving Nxf3
Mice homozygous for a knock-out allele exhibit normal fertility and male reproductive system morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018776 VEGA Gene Model | MGI Sequence Detail 13157 C57BL/6J ±  kb
transcript OTTMUST00000045144 VEGA | MGI Sequence Detail 2978 Not Applicable  
polypeptide OTTMUSP00000020293 VEGA | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    27 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 8
    cDNA 6
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 20
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:97549 Sasaki M, et al., Molecular cloning and functional characterization of mouse Nxf family gene products. Genomics. 2005 May;85(5):641-53
  • Latest
    J:200621 Vanmarsenille L, et al., Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability. PLoS One. 2013;8(5):e64144

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory