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Nxf3 Gene Detail
Summary
  • Symbol
    Nxf3
  • Name
    nuclear RNA export factor 3
  • Synonyms
    LOC245610
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685230
    NCBI Gene: 245610
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:136072099-136085255 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 57.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685230
protein coding gene ChrX:136072099-136085554 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036093
protein coding gene ChrX:133429807-133447929 (-)
A/J MGP_AJ_G0036074
protein coding gene ChrX:132831827-132844648 (-)
AKR/J MGP_AKRJ_G0036000
protein coding gene ChrX:137096406-137110567 (-)
BALB/cJ MGP_BALBcJ_G0036062
protein coding gene ChrX:131220149-131233550 (-)
C3H/HeJ MGP_C3HHeJ_G0035772
protein coding gene ChrX:133420362-133433557 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036585
protein coding gene ChrX:137264561-137277748 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033415
protein coding gene ChrX:124829621-124841977 (-)
CAST/EiJ MGP_CASTEiJ_G0035061
protein coding gene ChrX:114345371-114361441 (-)
CBA/J MGP_CBAJ_G0035748
protein coding gene ChrX:141485480-141502029 (-)
DBA/2J MGP_DBA2J_G0035903
protein coding gene ChrX:132175630-132189175 (-)
FVB/NJ MGP_FVBNJ_G0035839
protein coding gene ChrX:131343572-131357223 (-)
LP/J MGP_LPJ_G0035997
protein coding gene ChrX:134358834-134372622 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035873
protein coding gene ChrX:148874102-148888288 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036622
protein coding gene ChrX:132782747-132797928 (-)
PWK/PhJ MGP_PWKPhJ_G0034752
protein coding gene ChrX:111258289-111271558 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034583
protein coding gene ChrX:114995799-115008798 (-)
WSB/EiJ MGP_WSBEiJ_G0035194
protein coding gene ChrX:131120185-131133356 (-)



Homology
more
  • Human Ortholog
    NXF3, nuclear RNA export factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NXF3, nuclear RNA export factor 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 56000
    neXtProt AC: NX_Q9H4D5
    UniProt: Q9H4D5

  • Chr Location
    Xq22.1; chrX:103075821-103093094 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    3 phenotype references
Mice homozygous for a knock-out allele exhibit normal fertility and male reproductive system morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057000 Ensembl Gene Model | MGI Sequence Detail 13157 C57BL/6J ±  kb
transcript ENSMUST00000080929 Ensembl | MGI Sequence Detail 2978 Not Applicable  
polypeptide ENSMUSP00000079730 Ensembl | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR032710 NTF2-like domain superfamily
    IPR030217 Nuclear RNA export factor
    IPR030216 Nuclear RNA export factor 3
    IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
    IPR002075 Nuclear transport factor 2
    IPR018222 Nuclear transport factor 2, eukaryote
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR005637 TAP C-terminal (TAP-C) domain
    IPR009060 UBA-like superfamily
Molecular
Reagents
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  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 21
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:97549 Sasaki M, et al., Molecular cloning and functional characterization of mouse Nxf family gene products. Genomics. 2005 May;85(5):641-53
  • Latest
    J:210663 Zhou J, et al., Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome. Hum Mol Genet. 2014 Jul 15;23(14):3823-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory