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Gpr174 Gene Detail
Summary
  • Symbol
    Gpr174
  • Name
    G protein-coupled receptor 174
  • Synonyms
    LOC213439
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685222
    NCBI Gene: 213439
  • Gene Overview
    MyGene.info: GPR174
Location & Maps
more
  • Sequence Map
    ChrX:107255878-107296767 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40890 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 47.48 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GPR174, G protein-coupled receptor 174
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPR174, G protein-coupled receptor 174
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FKSG79, GPCR17, LYPSR3
  • Links
    NCBI Gene ID: 84636
    neXtProt AC: NX_Q9BXC1

  • Chr Location
    Xq21.1; chrX:79170972-79172229 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
Male mice hemizygous for a knock-out allele exhibit abnormal T cell proliferation, abnormal regulatory T cell physiology and decreased susceptibility to EAE.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018153 VEGA Gene Model | MGI Sequence Detail 40890 C57BL/6J ±  kb
transcript OTTMUST00000043854 VEGA | MGI Sequence Detail 3588 Not Applicable  
polypeptide OTTMUSP00000019693 VEGA | MGI Sequence Detail 335 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    94 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001640 G-protein coupled receptor 174
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 4
References
more
  • Summaries
    All 22
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:222307 Barnes MJ, et al., The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function. J Exp Med. 2015 Jun 29;212(7):1011-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory