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Xirp2 Gene Detail
Summary
  • Symbol
    Xirp2
  • Name
    xin actin-binding repeat containing 2
  • Synonyms
    2310003D02Rik, 2310008C07Rik, A530024P18Rik, Cmya3, mXin beta, myomaxin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685198
    NCBI Gene: 241431
  • Gene Overview
    MyGene.info: XIRP2
Location & Maps
more
  • Sequence Map
    Chr2:67446002-67526614 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80613 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.31 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    XIRP2, xin actin binding repeat containing 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    XIRP2, xin actin binding repeat containing 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMYA3
  • Links
    NCBI Gene ID: 129446
    neXtProt AC: NX_A4UGR9

  • Chr Location
    2q24.3; chr2:166888487-167259753 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Xirp2
  • Incidental Mutations
Homozygous null mice have an abnormal heart shape, ventricular septal defects, a failure of mature intercalated disc formation, severe growth retardation, and postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012905 VEGA Gene Model | MGI Sequence Detail 80613 C57BL/6J ±  kb
transcript OTTMUST00000030942 VEGA | MGI Sequence Detail 11979 Not Applicable  
polypeptide OTTMUSP00000013862 VEGA | MGI Sequence Detail 3283 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    721 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000017480 Xin actin-binding repeat-containing protein 2
  • InterPro Domains
    IPR012510 Actin-binding, Xin repeat
    IPR030072 Xin actin-binding repeat-containing protein 1/2
    IPR030107 Xin actin-binding repeat-containing protein 2
    IPR001781 Zinc finger, LIM-type
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 2
Other
Accession IDs
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MGI:1916705, MGI:1916775, MGI:2138966
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228182 Scheffer DI, et al., XIRP2, an actin-binding protein essential for inner ear hair-cell stereocilia. Cell Rep. 2015 Mar 24;10(11):1811-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory