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Dusp5
Gene Detail
 Symbol
Name
ID
Dusp5
dual specificity phosphatase 5
MGI:2685183
Synonyms LOC240672
Feature Type protein coding gene
Genetic Map
Chromosome 19
47.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:53529109-53542431 bp, + strand
From VEGA annotation of GRCm38

  13323 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dual specificity protein phosphatase (MAP kinase phosphatase)
Gene Tree: Dusp5

Human
homologs
Human Homolog DUSP5, dual specificity phosphatase 5
NCBI Gene ID 1847
neXtProt AC  NX_Q16690
Human Synonyms  DUSP, HVH3
Human Chr (Location)  10q25; chr10:110497867-110511544 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Interactions
Dusp5 interacts with 167 markers (Mir7-1, Mir16-1, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process dephosphorylation, endoderm formation, ...
Function hydrolase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (75)    Tissues (15)    Images (20)
Theiler Stages: 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 75
cDNA source data(4)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000029765 (Evidence)
Ensembl Gene ModelENSMUSG00000034765 (Evidence)
Entrez Gene240672 (Evidence)
DFCITC1755372
DoTSDT.528745
NIA Mouse Gene IndexU019572
EC3.1.3.16, 3.1.3.48
Consensus CDS ProjectCCDS38024.1
International Mouse Knockout Project StatusDusp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029765 VEGA Gene Model | MGI Sequence Detail 13323 C57BL/6J ±  kb
transcript OTTMUST00000073872 VEGA | MGI Sequence Detail 2473 Not Applicable 
polypeptide OTTMUSP00000038291 VEGA | MGI Sequence Detail 384 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
InterPro IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000006755 dual specificity protein phosphatase 5
References (Earliest) J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
(Latest) J:198483 Finelli MJ, et al., Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory