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Dusp5 Gene Detail
Summary
  • Symbol
    Dusp5
  • Name
    dual specificity phosphatase 5
  • Synonyms
    LOC240672
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685183
    NCBI Gene: 240672
  • Gene Overview
    MyGene.info: DUSP5
Location & Maps
more
  • Sequence Map
    Chr19:53529109-53542431 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13323 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 47.98 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DUSP5, dual specificity phosphatase 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DUSP5, dual specificity phosphatase 5
    Orthology source: HomoloGene
  • Synonyms
    DUSP, HVH3
  • Links
    NCBI Gene ID: 1847
    neXtProt AC: NX_Q16690

  • Chr Location
    10q25; chr10:110497867-110511544 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from multigenic genotypes
    1 images
    7 phenotype references
  • All Mutations and Alleles
    6
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029765 VEGA Gene Model | MGI Sequence Detail 13323 C57BL/6J ±  kb
transcript OTTMUST00000073872 VEGA | MGI Sequence Detail 2473 Not Applicable  
polypeptide OTTMUSP00000038291 VEGA | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    53 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • EC
  • InterPro Domains
    IPR024950 Dual specificity phosphatase
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR020422 Dual specificity protein phosphatase domain
    IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR001763 Rhodanese-like domain
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
  • Latest
    J:218203 Holmes DA, et al., Dusp5 negatively regulates IL-33-mediated eosinophil survival and function. EMBO J. 2015 Jan 14;34(2):218-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory