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Dusp5 Gene Detail
Summary
  • Symbol
    Dusp5
  • Name
    dual specificity phosphatase 5
  • Synonyms
    LOC240672
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685183
    NCBI Gene: 240672
  • Gene Overview
    MyGene.info: DUSP5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:53529318-53541322 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 47.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685183
protein coding gene Chr19:53529109-53542431 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025247
protein coding gene Chr19:53681735-53694761 (+)
A/J MGP_AJ_G0025223
protein coding gene Chr19:51033018-51046257 (+)
AKR/J MGP_AKRJ_G0025192
protein coding gene Chr19:52631191-52646547 (+)
BALB/cJ MGP_BALBcJ_G0025218
protein coding gene Chr19:51117412-51131014 (+)
C3H/HeJ MGP_C3HHeJ_G0024978
protein coding gene Chr19:52856834-52870173 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025661
protein coding gene Chr19:54972444-54988696 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023073
protein coding gene Chr19:50028450-50041444 (+)
CAST/EiJ MGP_CASTEiJ_G0024443
protein coding gene Chr19:52821696-52836515 (+)
CBA/J MGP_CBAJ_G0024958
protein coding gene Chr19:57703256-57716448 (+)
DBA/2J MGP_DBA2J_G0025090
protein coding gene Chr19:50845494-50858587 (+)
FVB/NJ MGP_FVBNJ_G0025051
protein coding gene Chr19:50545248-50558266 (+)
LP/J MGP_LPJ_G0025176
protein coding gene Chr19:53544564-53558974 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025084
protein coding gene Chr19:57156684-57170020 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025719
protein coding gene Chr19:52830502-52843603 (+)
PWK/PhJ MGP_PWKPhJ_G0024191
protein coding gene Chr19:50750659-50764026 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023994
protein coding gene Chr19:51504870-51517852 (+)
WSB/EiJ MGP_WSBEiJ_G0024513
protein coding gene Chr19:52967652-52980822 (+)



Homology
more
  • Human Ortholog
    DUSP5, dual specificity phosphatase 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DUSP5, dual specificity phosphatase 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DUSP, HVH3
  • Links
    NCBI Gene ID: 1847
    neXtProt AC: NX_Q16690
    UniProt: Q16690

  • Chr Location
    10q25.2; chr10:110497867-110511544 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 4 genetic backgrounds
    18 phenotypes from multigenic genotypes
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased proliferation and apoptosis and altered metabolic profiles in T cells. Mice homozygous for other null alleles exhibit altered eosinophilic response to parasicitc infection and increased susceptibility to induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 240672 NCBI Gene Model | MGI Sequence Detail 12005 C57BL/6J ±  kb
transcript NM_001085390 RefSeq | MGI Sequence Detail 1155 BTBR T<+> Itpr3/J  
polypeptide NP_001078859 RefSeq | MGI Sequence Detail 384 BTBR T<+> Itpr3/J  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • EC
  • InterPro Domains
    IPR024950 Dual specificity phosphatase
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR020422 Dual specificity protein phosphatase domain
    IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR001763 Rhodanese-like domain
    IPR036873 Rhodanese-like domain superfamily
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
  • Latest
    J:260220 Togel L, et al., DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis. Sci Rep. 2018 Jan 29;8(1):1767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory