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Megf10
Gene Detail
 Symbol
Name
ID
Megf10
multiple EGF-like-domains 10
MGI:2685177
Synonyms 3000002B06Rik, LOC240312
Feature Type protein coding gene
Genetic Map
Chromosome 18
31.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:57133090-57297467 bp, + strand
From VEGA annotation of GRCm38

  164378 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23771  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Megf10

Human
homologs
Human Homolog MEGF10, multiple EGF-like-domains 10
NCBI Gene ID 84466
neXtProt AC  NX_Q96KG7
Human Synonyms  EMARDD
Human Chr (Location)  5q33; chr5:127290764-127461222 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MEGF10
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit abnormal spacing of starburst amacrine cells and horizontal cells. Mice heterozygous for thie same allele exhibit mild disorganization of starburts amacrine cells.
 
Interactions
Megf10 interacts with 372 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell adhesion, homotypic cell-cell adhesion, ...
Component cell projection, integral component of membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000024354 (Evidence)
Ensembl Gene ModelENSMUSG00000024593 (Evidence)
Entrez Gene70417 (Evidence)
UniGene297863
DFCITC1602365
DoTSDT.101231214, DT.60104768
NIA Mouse Gene IndexU112841
Consensus CDS ProjectCCDS29264.1
International Mouse Knockout Project StatusMegf10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024354 VEGA Gene Model | MGI Sequence Detail 164378 C57BL/6J ±  kb
transcript OTTMUST00000059657 VEGA | MGI Sequence Detail 7514 Not Applicable 
polypeptide OTTMUSP00000029036 VEGA | MGI Sequence Detail 1147 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(1056 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR011489 EMI domain
InterPro IPR000742 Epidermal growth factor-like domain
Protein Ontology PR:000010314 multiple epidermal growth factor-like domains protein 10
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(35)
Other
accession IDs
MGI:1917667

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory