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Ccdc154 Gene Detail
Summary
  • Symbol
    Ccdc154
  • Name
    coiled-coil domain containing 154
  • Synonyms
    LOC207209, ntl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685163
    NCBI Gene: 207209
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25162461-25171913 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685163
protein coding gene Chr17:25162175-25171913 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023341
protein coding gene Chr17:24204784-24215488 (+)
A/J MGP_AJ_G0023300
protein coding gene Chr17:23530512-23539908 (+)
AKR/J MGP_AKRJ_G0023266
protein coding gene Chr17:23621371-23630796 (+)
BALB/cJ MGP_BALBcJ_G0023305
protein coding gene Chr17:23727083-23736428 (+)
C3H/HeJ MGP_C3HHeJ_G0023065
protein coding gene Chr17:23997899-24007282 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023748
protein coding gene Chr17:25269151-25278603 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021223
protein coding gene Chr17:20991092-21000549 (+)
CAST/EiJ MGP_CASTEiJ_G0022567
protein coding gene Chr17:23844734-23854138 (+)
CBA/J MGP_CBAJ_G0023040
protein coding gene Chr17:26126442-26137998 (+)
DBA/2J MGP_DBA2J_G0023170
protein coding gene Chr17:23118796-23128192 (+)
FVB/NJ MGP_FVBNJ_G0023140
protein coding gene Chr17:22840365-22850595 (+)
LP/J MGP_LPJ_G0023247
protein coding gene Chr17:24498293-24507739 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023159
protein coding gene Chr17:25790201-25799594 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023787
protein coding gene Chr17:23903960-23913356 (+)
PWK/PhJ MGP_PWKPhJ_G0022316
protein coding gene Chr17:21880399-21889853 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022134
protein coding gene Chr17:21977223-21986712 (+)
WSB/EiJ MGP_WSBEiJ_G0022630
protein coding gene Chr17:23975210-23984604 (+)



Homology
more
  • Human Ortholog
    CCDC154, coiled-coil domain containing 154
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCDC154, coiled-coil domain containing 154
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C16orf29
  • Links
    NCBI Gene ID: 645811
    neXtProt AC: NX_A6NI56
    UniProt: A6NI56

  • Chr Location
    16p13.3; chr16:1434388-1444489 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ccdc154 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit failure of tooth eruption, osteopetrosis, enlarged liver, decreased body size and premature death unless fed a liquid diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059562 Ensembl Gene Model | MGI Sequence Detail 9453 C57BL/6J ±  kb
transcript ENSMUST00000182621 Ensembl | MGI Sequence Detail 2402 Not Applicable  
polypeptide ENSMUSP00000138090 Ensembl | MGI Sequence Detail 664 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
Other
Accession IDs
less
MGI:5702427
References
more
  • Summaries
    All 21
    Diseases 1
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:86784 Bergstrom DE, et al., Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome. 2003 Dec;14(12):817-29
  • Latest
    J:244484 Liao W, et al., Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses cell proliferation by inducing G2/M arrest. Cell Cycle. 2012 Sep 01;11(17):3270-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory