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Setdb2
Gene Detail
 Symbol
Name
ID
Setdb2
SET domain, bifurcated 2
MGI:2685139
Synonyms KMT1F, LOC239122
Feature Type protein coding gene
Genetic Map
Chromosome 14
31.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:59402009-59440884 bp, - strand
From VEGA annotation of GRCm38

  38876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12903  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Setdb2

Human
homologs
Human Homolog SETDB2, SET domain, bifurcated 2
NCBI Gene ID 83852
neXtProt AC  NX_Q96T68
Human Synonyms  C13orf4, CLLD8, CLLL8, KMT1F
Human Chr (Location)  13q14; chr13:49444166-49495003 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Setdb2 interacts with 121 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell cycle, cell division, ...
Component chromosome, nucleus
Function DNA binding, histone-lysine N-methyltransferase activity, ...
Expression
Literature Summary: (3 records)
Data Summary: Results (137)    Tissues (108)    Images (13)
Theiler Stages: 20, 22, 23, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 125
Northern blot 2
Western blot 3
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(27) Primer pair(2)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000033346 (Evidence)
Ensembl Gene ModelENSMUSG00000071350 (Evidence)
Entrez Gene239122 (Evidence)
UniGene205022
DFCITC1587705
DoTSDT.101173338
NIA Mouse Gene IndexU035638
EC2.1.1.43
Consensus CDS ProjectCCDS36939.1
International Mouse Knockout Project StatusSetdb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033346 VEGA Gene Model | MGI Sequence Detail 38876 C57BL/6J ±  kb
transcript OTTMUST00000083696 VEGA | MGI Sequence Detail 2995 Not Applicable 
polypeptide OTTMUSP00000045004 VEGA | MGI Sequence Detail 697 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(9)
Polymorphisms SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016177 DNA-binding, integrase-type
InterPro IPR001739 Methyl-CpG DNA binding
InterPro IPR007728 Pre-SET domain
InterPro IPR001214 SET domain
Protein Ontology PR:000014725 histone-lysine N-methyltransferase SETDB2
References (Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory