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Setdb2
Gene Detail
Symbol

Name
ID
Setdb2
SET domain, bifurcated 2
MGI:2685139
Synonyms
KMT1F, LOC239122
Feature Type
protein coding gene
Genetic Map
Chromosome 14
31.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:59402009-59440884 bp, - strand
From VEGA annotation of GRCm38

  38876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12903  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: SETDB2
Gene Tree: Setdb2

Human
homologs
SETDB2, SET domain, bifurcated 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 83852
neXtProt AC: NX_Q96T68

Human Synonyms: C13orf4, CLLD8, CLLL8, KMT1F

Human Chr (Location): 13q14; chr13:49444056-49495003 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Setdb2 interacts with 120 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell cycle, cell division, ...
Component chromosome, nucleus
Function DNA binding, histone-lysine N-methyltransferase activity, ...
Expression
Literature Summary: (4 records)
Data Summary: Results (137)    Tissues (108)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 125
Northern blot 2
Western blot 3
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase setdb2    NEW 
Molecular
reagents
All nucleic(29) cDNA(27) Primer pair(2)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000033346 (Evidence)
Ensembl Gene Model ENSMUSG00000071350 (Evidence)
Entrez Gene 239122 (Evidence)
UniGene 205022
DFCI TC1587705
DoTS DT.101173338
NIA Mouse Gene Index U035638
EC 2.1.1.43
Consensus CDS Project CCDS36939.1
International Mouse Phenotyping Consortium Status Setdb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033346 VEGA Gene Model | MGI Sequence Detail 38876 C57BL/6J ±  kb
transcript OTTMUST00000083696 VEGA | MGI Sequence Detail 2995 Not Applicable 
polypeptide OTTMUSP00000045004 VEGA | MGI Sequence Detail 697 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(9)
Polymorphisms
SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016177 DNA-binding, integrase-type
InterPro IPR001739 Methyl-CpG DNA binding
InterPro IPR007728 Pre-SET domain
InterPro IPR001214 SET domain
Protein Ontology PR:000014725 histone-lysine N-methyltransferase SETDB2
References
(Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:216177 Labialle S, et al., The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory