About   Help   FAQ
Ism2 Gene Detail
Summary
  • Symbol
    Ism2
  • Name
    isthmin 2
  • Synonyms
    LOC217738, Thsd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685110
    NCBI Gene: 217738
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr12:87278638-87299705 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 41.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685110
protein coding gene Chr12:87278638-87299850 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019985
protein coding gene Chr12:88178339-88202991 (-)
A/J MGP_AJ_G0019943
protein coding gene Chr12:84829880-84851700 (-)
AKR/J MGP_AKRJ_G0019918
protein coding gene Chr12:87135521-87158460 (-)
BALB/cJ MGP_BALBcJ_G0019922
protein coding gene Chr12:85162629-85183450 (-)
C3H/HeJ MGP_C3HHeJ_G0019728
protein coding gene Chr12:87623563-87646567 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020374
protein coding gene Chr12:90720721-90745427 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017992
protein coding gene Chr12:81709217-81731176 (-)
CAST/EiJ MGP_CASTEiJ_G0019278
protein coding gene Chr12:82653831-82678959 (-)
CBA/J MGP_CBAJ_G0019700
protein coding gene Chr12:94192149-94213113 (-)
DBA/2J MGP_DBA2J_G0019813
protein coding gene Chr12:84325123-84346568 (-)
FVB/NJ MGP_FVBNJ_G0019800
protein coding gene Chr12:83319199-83340930 (-)
LP/J MGP_LPJ_G0019887
protein coding gene Chr12:88059263-88080227 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019839
protein coding gene Chr12:96955926-96980234 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020406
protein coding gene Chr12:86760675-86781722 (-)
PWK/PhJ MGP_PWKPhJ_G0019042
protein coding gene Chr12:78879304-78903437 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018837
protein coding gene Chr12:81265982-81293890 (-)
WSB/EiJ MGP_WSBEiJ_G0019331
protein coding gene Chr12:87538320-87559270 (-)



Homology
more
  • Human Ortholog
    ISM2, isthmin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ISM2, isthmin 2
    Orthology source: HGNC
  • Synonyms
    TAIL1, THSD3
  • Links
    NCBI Gene ID: 145501
    neXtProt AC: NX_Q6H9L7
    UniProt: Q6H9L7

  • Chr Location
    14q24.3; chr14:77474394-77498867 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 83509
    1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ISM2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050671 Ensembl Gene Model | MGI Sequence Detail 21068 C57BL/6J ±  kb
transcript ENSMUST00000125733 Ensembl | MGI Sequence Detail 2526 Not Applicable  
polypeptide ENSMUSP00000117108 Ensembl | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 21
    Developmental Gene Expression 1
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/03/2019
MGI 6.14
The Jackson Laboratory