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Ism2 Gene Detail
Summary
  • Symbol
    Ism2
  • Name
    isthmin 2
  • Synonyms
    LOC217738, Thsd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685110
    NCBI Gene: 217738
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr12:87278638-87299705 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 41.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685110
protein coding gene Chr12:87278638-87299850 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019985
protein coding gene Chr12:88178339-88202991 (-)
A/J MGP_AJ_G0019943
protein coding gene Chr12:84829880-84851700 (-)
AKR/J MGP_AKRJ_G0019918
protein coding gene Chr12:87135521-87158460 (-)
BALB/cJ MGP_BALBcJ_G0019922
protein coding gene Chr12:85162629-85183450 (-)
C3H/HeJ MGP_C3HHeJ_G0019728
protein coding gene Chr12:87623563-87646567 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020374
protein coding gene Chr12:90720721-90745427 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017992
protein coding gene Chr12:81709217-81731176 (-)
CAST/EiJ MGP_CASTEiJ_G0019278
protein coding gene Chr12:82653831-82678959 (-)
CBA/J MGP_CBAJ_G0019700
protein coding gene Chr12:94192149-94213113 (-)
DBA/2J MGP_DBA2J_G0019813
protein coding gene Chr12:84325123-84346568 (-)
FVB/NJ MGP_FVBNJ_G0019800
protein coding gene Chr12:83319199-83340930 (-)
LP/J MGP_LPJ_G0019887
protein coding gene Chr12:88059263-88080227 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019839
protein coding gene Chr12:96955926-96980234 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020406
protein coding gene Chr12:86760675-86781722 (-)
PWK/PhJ MGP_PWKPhJ_G0019042
protein coding gene Chr12:78879304-78903437 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018837
protein coding gene Chr12:81265982-81293890 (-)
WSB/EiJ MGP_WSBEiJ_G0019331
protein coding gene Chr12:87538320-87559270 (-)



Homology
more
  • Human Ortholog
    ISM2, isthmin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ISM2, isthmin 2
    Orthology source: HGNC
  • Synonyms
    TAIL1, THSD3
  • Links
    NCBI Gene ID: 145501
    neXtProt AC: NX_Q6H9L7
    UniProt: Q6H9L7

  • Chr Location
    14q24.3; chr14:77474394-77498867 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 83509
    1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ISM2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050671 Ensembl Gene Model | MGI Sequence Detail 21068 C57BL/6J ±  kb
transcript ENSMUST00000125733 Ensembl | MGI Sequence Detail 2526 Not Applicable  
polypeptide ENSMUSP00000117108 Ensembl | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 21
    Developmental Gene Expression 1
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory