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Ism2 Gene Detail
Summary
  • Symbol
    Ism2
  • Name
    isthmin 2
  • Synonyms
    LOC217738, Thsd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685110
    NCBI Gene: 217738
Location & Maps
more
  • Sequence Map
    Chr12:87278638-87299705 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21068 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 41.49 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ISM2, isthmin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ISM2, isthmin 2
    Orthology source: HGNC
  • Synonyms
    TAIL1, THSD3
  • Links
    NCBI Gene ID: 145501
    neXtProt AC: NX_Q6H9L7

  • Chr Location
    14q24.3; chr14:77474394-77498867 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 83509
    1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ISM2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    5
  • Genomic Mutations
    1 involving Ism2
  • Incidental Mutations
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032853 VEGA Gene Model | MGI Sequence Detail 21068 C57BL/6J ±  kb
transcript OTTMUST00000081862 VEGA | MGI Sequence Detail 2526 Not Applicable  
polypeptide OTTMUSP00000043846 VEGA | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    112 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR005533 AMOP domain
    IPR000884 Thrombospondin type-1 (TSP1) repeat
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 19
    Developmental Gene Expression 1
    Phenotypes 7
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory