Samd15 Gene Detail

Summary

• Symbol
  Samd15
• Name
  sterile alpha motif domain containing 15
• Synonyms
  Gm263, LOC238333

• Feature Type
  protein coding gene
• IDs
  MGI:2685109
  NCBI Gene: 238333
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr12:87199723-87213541 bp, + strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 41.40 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  44 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685109	protein coding gene	Chr12:87194484-87213541 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019981	protein coding gene	Chr12:88096247-88111399 (+)
A/J	MGP_AJ_G0019939	protein coding gene	Chr12:84750042-84763796 (+)
AKR/J	MGP_AKRJ_G0019914	protein coding gene	Chr12:87048992-87062715 (+)
BALB/cJ	MGP_BALBcJ_G0019918	protein coding gene	Chr12:85083038-85097101 (+)
C3H/HeJ	MGP_C3HHeJ_G0019724	protein coding gene	Chr12:87537572-87557623 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020370	protein coding gene	Chr12:90629797-90648816 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017988	protein coding gene	Chr12:81628178-81640246 (+)
CAST/EiJ	MGP_CASTEiJ_G0019274	protein coding gene	Chr12:82563253-82576881 (+)
CBA/J	MGP_CBAJ_G0019696	protein coding gene	Chr12:94112326-94127145 (+)
DBA/2J	MGP_DBA2J_G0019809	protein coding gene	Chr12:84244861-84258833 (+)
FVB/NJ	MGP_FVBNJ_G0019796	protein coding gene	Chr12:83238081-83252573 (+)
LP/J	MGP_LPJ_G0019883	protein coding gene	Chr12:87977478-87991961 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019835	protein coding gene	Chr12:96872919-96887424 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020402	protein coding gene	Chr12:86678758-86694987 (+)
PWK/PhJ	MGP_PWKPhJ_G0019038	protein coding gene	Chr12:78797285-78811512 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018833	protein coding gene	Chr12:81181372-81198752 (+)
WSB/EiJ	MGP_WSBEiJ_G0019327	protein coding gene	Chr12:87454422-87469094 (+)

Homology

• Human Ortholog
  SAMD15, sterile alpha motif domain containing 15

• Vertebrate Orthologs
  7

• Human Ortholog
  SAMD15, sterile alpha motif domain containing 15
  Orthology source: HomoloGene, HGNC
• Synonyms
  C14orf174, FAM15A
• Links
  HGNC:18631

  NCBI Gene ID: 161394

  neXtProt AC: NX_Q9P1V8

  UniProt: Q9P1V8

  
  
• Chr Location
  14q24.3; chr14:77377419-77391244 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 52875
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
  
• HCOP
  human homology predictions: SAMD15
• Gene Tree
  Samd15
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  12
• Chemically induced (other)
  1
• Gene trapped
  11
• Genomic Mutations
  1 involving Samd15
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  7 strains or lines available

Expression

• Assay Results
  631
• cDNA Data
  4

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  33
• RefSeq
  3
• UniProt
  2
• CCDS
  CCDS70409.1
• UniGene
  302304

• Ensembl
  ENSMUSG00000090812 (Evidence)
• NCBI Gene
  238333

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000090812	Ensembl Gene Model | MGI Sequence Detail	13819	C57BL/6J
transcript	ENSMUST00000182869	Ensembl | MGI Sequence Detail	2031	Not Applicable
polypeptide	ENSMUSP00000138551	Ensembl | MGI Sequence Detail	620	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000030686 sterile alpha motif domain-containing protein 15
  (term hierarchy)
• InterPro Domains
  IPR001660 Sterile alpha motif domain
  IPR042554 Sterile alpha motif domain-containing protein 15
  IPR013761 Sterile alpha motif/pointed domain superfamily

Molecular
Reagents

• All nucleic 4

  cDNA 4

References

• Summaries
  All 18

  Phenotypes 5
• Earliest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Samd15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114517	Chr12:87200336-87200345 (+)	618 bp
Tssr114518	Chr12:87200502-87200522 (+)	789 bp
Tssr114519	Chr12:87200524-87200544 (+)	811 bp