Slc30a10 MGI Mouse Gene Detail - MGI:2685058 - solute carrier family 30, member 10

Symbol

Slc30a10
Name

solute carrier family 30, member 10
Synonyms

E130106K10Rik

Feature Type

protein coding gene
IDs

MGI:2685058
NCBI Gene: 226781
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:185454848-185468762 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 89.53 cM
Mapping Data

2 experiments

SNPs within 2kb

212 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685058	protein coding gene	Chr1:185454848-185468762 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016917	protein coding gene	Chr1:192193985-192207829 (+)
A/J	MGP_AJ_G0016896	protein coding gene	Chr1:184332045-184345911 (+)
AKR/J	MGP_AKRJ_G0016861	protein coding gene	Chr1:189766042-189779888 (+)
BALB/cJ	MGP_BALBcJ_G0016854	protein coding gene	Chr1:184974098-184987976 (+)
C3H/HeJ	MGP_C3HHeJ_G0016678	protein coding gene	Chr1:190634100-190647973 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017317	protein coding gene	Chr1:198325977-198339860 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015024	protein coding gene	Chr1:175320033-175332684 (+)
CAST/EiJ	MGP_CASTEiJ_G0016261	protein coding gene	Chr1:190065261-190079048 (+)
CBA/J	MGP_CBAJ_G0016652	protein coding gene	Chr1:205723159-205736957 (+)
DBA/2J	MGP_DBA2J_G0016758	protein coding gene	Chr1:183090534-183104154 (+)
FVB/NJ	MGP_FVBNJ_G0016754	protein coding gene	Chr1:181191489-181205360 (+)
LP/J	MGP_LPJ_G0016833	protein coding gene	Chr1:193343150-193356996 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016786	protein coding gene	Chr1:212594276-212608159 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017354	protein coding gene	Chr1:189638172-189652074 (+)
PWK/PhJ	MGP_PWKPhJ_G0016048	protein coding gene	Chr1:182302970-182316927 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015824	protein coding gene	Chr1:188593109-188606712 (+)
WSB/EiJ	MGP_WSBEiJ_G0016323	protein coding gene	Chr1:189802153-189815772 (+)

Human Ortholog

SLC30A10, solute carrier family 30 member 10

Vertebrate Orthologs

9

Human Ortholog

SLC30A10, solute carrier family 30 member 10
Orthology source: HomoloGene, HGNC
Synonyms

HMDPC, HMNDYT1, ZnT-10, ZNT10, ZNT8, ZRC1
Links

HGNC:25355

NCBI Gene ID: 55532

neXtProt AC: NX_Q6XR72

UniProt: Q6XR72
Chr Location

1q41; chr1:219910398-219959754 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 100946
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SLC30A10
Protein SuperFamily

cation efflux protein
Gene Tree

Slc30a10

Diseases

1 with human SLC30A10 associations

				Human Disease	Mouse Models
				hypermanganesemia with dystonia 1 IDs hypermanganesemia with dystonia 1 DOID:0080536 OMIM:613280

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

23 phenotypes from 2 alleles in 2 genetic backgrounds
2 images
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit post-weaning growth defects, increased manganese levels in the brain, blood, liver and thyroid gland, severe hypothyroidism and premature death.

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All GO Annotations

28
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

660
Tissues

29
cDNA Data

25
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc30a10

ZFIN slc30a10

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Slc30a10 interacts with 388 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS15599.1
UniGene

227117

Ensembl

ENSMUSG00000026614 (Evidence)
NCBI Gene

226781

			Length	Strain/Species	Flank
genomic	226781	NCBI Gene Model \| MGI Sequence Detail	13915	C57BL/6J	± kb
transcript	NM_001033286	RefSeq \| MGI Sequence Detail	5836	C57BL/6
polypeptide	Q3UVU3	UniProt \| EBI \| MGI Sequence Detail	470	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015074 zinc transporter 10

(term hierarchy)
InterPro Domains

IPR002524 Cation efflux protein

IPR027469 Cation efflux transmembrane domain superfamily

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All nucleic 27

Genomic 1

cDNA 25

Primer pair 1

Microarray probesets 4

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 5
Earliest

J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
Latest

J:284835 Mercadante CJ, et al., Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity. J Clin Invest. 2019 Dec 2;129(12):5442-5461

TSS for Slc30a10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10615	Chr1:185454775-185454800 (+)	-60 bp
Tssr10616	Chr1:185454803-185454817 (+)	-38 bp
Tssr10617	Chr1:185454913-185454931 (+)	74 bp
Tssr10618	Chr1:185454980-185454995 (+)	140 bp
Tssr10619	Chr1:185455052-185455088 (+)	222 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16