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Slc30a10 Gene Detail
Summary
  • Symbol
    Slc30a10
  • Name
    solute carrier family 30, member 10
  • Synonyms
    E130106K10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685058
    NCBI Gene: 226781
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:185454848-185468762 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 89.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    212 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685058
protein coding gene Chr1:185454848-185468762 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016917
protein coding gene Chr1:192193985-192207829 (+)
A/J MGP_AJ_G0016896
protein coding gene Chr1:184332045-184345911 (+)
AKR/J MGP_AKRJ_G0016861
protein coding gene Chr1:189766042-189779888 (+)
BALB/cJ MGP_BALBcJ_G0016854
protein coding gene Chr1:184974098-184987976 (+)
C3H/HeJ MGP_C3HHeJ_G0016678
protein coding gene Chr1:190634100-190647973 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017317
protein coding gene Chr1:198325977-198339860 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015024
protein coding gene Chr1:175320033-175332684 (+)
CAST/EiJ MGP_CASTEiJ_G0016261
protein coding gene Chr1:190065261-190079048 (+)
CBA/J MGP_CBAJ_G0016652
protein coding gene Chr1:205723159-205736957 (+)
DBA/2J MGP_DBA2J_G0016758
protein coding gene Chr1:183090534-183104154 (+)
FVB/NJ MGP_FVBNJ_G0016754
protein coding gene Chr1:181191489-181205360 (+)
LP/J MGP_LPJ_G0016833
protein coding gene Chr1:193343150-193356996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016786
protein coding gene Chr1:212594276-212608159 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017354
protein coding gene Chr1:189638172-189652074 (+)
PWK/PhJ MGP_PWKPhJ_G0016048
protein coding gene Chr1:182302970-182316927 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015824
protein coding gene Chr1:188593109-188606712 (+)
WSB/EiJ MGP_WSBEiJ_G0016323
protein coding gene Chr1:189802153-189815772 (+)



Homology
more
  • Human Ortholog
    SLC30A10, solute carrier family 30 member 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC30A10, solute carrier family 30 member 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMDPC, HMNDYT1, ZnT-10, ZNT10, ZNT8, ZRC1
  • Links
    NCBI Gene ID: 55532
    neXtProt AC: NX_Q6XR72
    UniProt: Q6XR72

  • Chr Location
    1q41; chr1:219910398-219959754 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit post-weaning growth defects, increased manganese levels in the brain, blood, liver and thyroid gland, severe hypothyroidism and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226781 NCBI Gene Model | MGI Sequence Detail 13915 C57BL/6J ±  kb
    transcript NM_001033286 RefSeq | MGI Sequence Detail 5836 C57BL/6  
    polypeptide Q3UVU3 UniProt | EBI | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 25
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 4
    • Earliest
      J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
    • Latest
      J:246025 Liu C, et al., Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production. J Biol Chem. 2017 Oct 06;292(40):16605-16615

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory