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Slc30a10 Gene Detail
Summary
  • Symbol
    Slc30a10
  • Name
    solute carrier family 30, member 10
  • Synonyms
    E130106K10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685058
    NCBI Gene: 226781
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:185454848-185468762 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      13915 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 89.53 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC30A10, solute carrier family 30 member 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC30A10, solute carrier family 30 member 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMDPC, HMNDYT1, ZnT-10, ZNT10, ZNT8, ZRC1
  • Links
    NCBI Gene ID: 55532
    neXtProt AC: NX_Q6XR72
    UniProt: Q6XR72

  • Chr Location
    1q41; chr1:219910398-219959754 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit post-weaning growth defects, increased manganese levels in the brain, blood, liver and thyroid gland, severe hypothyroidism and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    29
  • Tissues
    29
  • cDNA Data
    25
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226781 NCBI Gene Model | MGI Sequence Detail 13915 C57BL/6J ±  kb
    transcript NM_001033286 RefSeq | MGI Sequence Detail 5836 C57BL/6  
    polypeptide Q3UVU3 UniProt | EBI | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      212 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 25
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
    • Latest
      J:246025 Liu C, et al., Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production. J Biol Chem. 2017 Oct 06;292(40):16605-16615
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    07/31/2018
    MGI 6.12     		The Jackson Laboratory