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Pik3c2b Gene Detail
Summary
  • Symbol
    Pik3c2b
  • Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
  • Synonyms
    C330011J12Rik, PI3K-C2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685045
    NCBI Gene: 240752
  • Gene Overview
    MyGene.info: PIK3C2B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:133045667-133108687 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63021 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.75 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PIK3C2B, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PIK3C2B, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C2-PI3K
  • Links
    NCBI Gene ID: 5287
    neXtProt AC: NX_O00750
    UniProt: O00750

  • Chr Location
    1q32.1; chr1:204422630-204494815 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Mice homozygous for a knock-out allele exhibit normal epidermal growth, differentiation and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021915 VEGA Gene Model | MGI Sequence Detail 63021 C57BL/6J ±  kb
transcript OTTMUST00000052037 VEGA | MGI Sequence Detail 7928 Not Applicable  
polypeptide OTTMUSP00000024586 VEGA | MGI Sequence Detail 1632 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    584 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR000008 C2 domain
    IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
    IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
    IPR002420 Phosphatidylinositol 3-kinase, C2 domain
    IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
    IPR015433 Phosphatidylinositol kinase
    IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
    IPR001683 Phox homologous domain
    IPR011009 Protein kinase-like domain superfamily
    IPR029071 Ubiquitin-like domain superfamily
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 1
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:237297 Sabha N, et al., PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models. J Clin Invest. 2016 Sep 01;126(9):3613-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/17/2017
MGI 6.10
The Jackson Laboratory