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Pik3c2b
Gene Detail
Symbol

Name
ID
Pik3c2b
phosphoinositide-3-kinase, class 2, beta polypeptide
MGI:2685045
Synonyms
C330011J12Rik, PI3K-C2beta
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:133045667-133108687 bp, + strand
From VEGA annotation of GRCm38

  63021 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20582  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pik3c2b

Human
homologs
Human Homolog PIK3C2B, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
NCBI Gene ID 5287
neXtProt AC  NX_O00750
Human Synonyms  C2-PI3K
Human Chr (Location)  1q32; chr1:204422628-204494815 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(10) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal epidermal growth, differentiation and function.
 
Interactions
Pik3c2b interacts with 364 markers (Mir1b, Mir7-1, Mir7-2, ...)
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000021915 (Evidence)
Ensembl Gene ModelENSMUSG00000026447 (Evidence)
Entrez Gene240752 (Evidence)
UniGene387308
DFCITC1610275
DoTSDT.97374355, DT.87053630
NIA Mouse Gene IndexU000808
Consensus CDS ProjectCCDS48360.1
International Mouse Knockout Project StatusPik3c2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021915 VEGA Gene Model | MGI Sequence Detail 63021 C57BL/6J ±  kb
transcript OTTMUST00000052037 VEGA | MGI Sequence Detail 7928 Not Applicable 
polypeptide OTTMUSP00000024586 VEGA | MGI Sequence Detail 1632 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(9) UniProt(6)
Polymorphisms
SNPs within 2kb(588 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR002420 Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR001683 Phox homologous domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000012716 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory