About   Help   FAQ
Rdh8
Gene Detail
 Symbol
Name
ID
Rdh8
retinol dehydrogenase 8
MGI:2685028
Synonyms LOC235033, prRDH
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:20818504-20826163 bp, + strand
From NCBI annotation of GRCm38

  7660 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: estradiol 17beta-dehydrogenase
Gene Tree: Rdh8

Human
homologs
Human Homolog RDH8, retinol dehydrogenase 8 (all-trans)
NCBI Gene ID 50700
neXtProt AC  NX_Q9NYR8
Human Synonyms  PRRDH, SDR28C2
Human Chr (Location)  19p13.2; chr19:10013249-10022278 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygous null mice are viable and fertile but display delayed dark adaptation.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process oxidation-reduction process, retinol metabolic process, ...
Function retinol dehydrogenase activity
External Resources: FuncBase
Expression
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(2) Other(2)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000053773 (Evidence)
Entrez Gene235033 (Evidence)
Consensus CDS ProjectCCDS22884.1
International Mouse Knockout Project StatusRdh8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 235033 NCBI Gene Model | MGI Sequence Detail 7660 C57BL/6J ±  kb
transcript NM_001030290 RefSeq | MGI Sequence Detail 1450 Not Specified 
polypeptide NP_001025461 RefSeq | MGI Sequence Detail 317 Not Specified 

For the selected sequences
All sequences(9) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011348 17beta-dehydrogenase
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000013855 retinol dehydrogenase 8
References (Earliest) J:99930 Maeda A, et al., Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13;280(19):18822-32
(Latest) J:210001 Kohno H, et al., CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol. 2014 Apr 15;192(8):3816-27
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory