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Rdh8
Gene Detail
Symbol

Name
ID
Rdh8
retinol dehydrogenase 8
MGI:2685028
Synonyms
LOC235033, prRDH
Feature Type
protein coding gene
Genetic Map
Chromosome 9
7.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:20818504-20826163 bp, + strand
From NCBI annotation of GRCm38

  7660 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RDH8
Protein SuperFamily: estradiol 17beta-dehydrogenase
Gene Tree: Rdh8

Human
homologs
RDH8, retinol dehydrogenase 8 (all-trans)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 50700
neXtProt AC: NX_Q9NYR8

Human Synonyms: PRRDH, SDR28C2

Human Chr (Location): 19p13.2; chr19:10013249-10022278 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous null mice are viable and fertile but display delayed dark adaptation.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Rdh8 interacts with 81 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process oxidation-reduction process, retinol metabolic process, ...
Function retinol dehydrogenase activity
External Resources: FuncBase
Expression
Other mouse links: GEO   Expression Atlas
Other vertebrate links: ZFIN rdh8a, rdh8b    NEW 
Molecular
reagents
All nucleic(2) Other(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000053773 (Evidence)
Entrez Gene 235033 (Evidence)
Consensus CDS Project CCDS22884.1
International Mouse Phenotyping Consortium Status Rdh8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 235033 NCBI Gene Model | MGI Sequence Detail 7660 C57BL/6J ±  kb
transcript NM_001030290 RefSeq | MGI Sequence Detail 1450 Not Specified 
polypeptide NP_001025461 RefSeq | MGI Sequence Detail 317 Not Specified 

For the selected sequences
All sequences(9) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011348 17beta-dehydrogenase
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000013855 retinol dehydrogenase 8
References
(Earliest) J:99930 Maeda A, et al., Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13;280(19):18822-32
(Latest) J:213619 Wu Y, et al., Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'. Biochem J. 2014 Jun 15;460(3):343-52
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory