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Rdh8 Gene Detail
Summary
  • Symbol
    Rdh8
  • Name
    retinol dehydrogenase 8
  • Synonyms
    LOC235033, prRDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685028
    NCBI Gene: 235033
  • Gene Overview
    MyGene.info: RDH8
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20818503-20826117 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685028
protein coding gene Chr9:20818503-20826163 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034427
protein coding gene Chr9:17980026-17991946 (+)
A/J MGP_AJ_G0034405
protein coding gene Chr9:17687708-17695473 (+)
AKR/J MGP_AKRJ_G0034332
protein coding gene Chr9:18004574-18012233 (+)
BALB/cJ MGP_BALBcJ_G0034396
protein coding gene Chr9:17587214-17594873 (+)
C3H/HeJ MGP_C3HHeJ_G0034108
protein coding gene Chr9:18320140-18327799 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034917
protein coding gene Chr9:18700134-18707793 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031847
protein coding gene Chr9:16819379-16827110 (+)
CAST/EiJ MGP_CASTEiJ_G0033431
protein coding gene Chr9:18142558-18150190 (+)
CBA/J MGP_CBAJ_G0034081
protein coding gene Chr9:19421342-19432456 (+)
DBA/2J MGP_DBA2J_G0034240
protein coding gene Chr9:17677283-17684942 (+)
FVB/NJ MGP_FVBNJ_G0034183
protein coding gene Chr9:17181267-17189186 (+)
LP/J MGP_LPJ_G0034325
protein coding gene Chr9:18162143-18169828 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034226
protein coding gene Chr9:21047511-21055656 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034937
protein coding gene Chr9:17959995-17969069 (+)
PWK/PhJ MGP_PWKPhJ_G0033137
protein coding gene Chr9:17644576-17652599 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032971
protein coding gene Chr9:18005486-18014614 (+)
WSB/EiJ MGP_WSBEiJ_G0033546
protein coding gene Chr9:17690177-17699053 (+)



Homology
more
  • Human Ortholog
    RDH8, retinol dehydrogenase 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RDH8, retinol dehydrogenase 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRRDH, SDR28C2
  • Links
    NCBI Gene ID: 50700
    neXtProt AC: NX_Q9NYR8
    UniProt: Q9NYR8

  • Chr Location
    19p13.2; chr19:10013249-10022278 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile but display delayed dark adaptation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053773 Ensembl Gene Model | MGI Sequence Detail 7615 C57BL/6J ±  kb
transcript ENSMUST00000066387 Ensembl | MGI Sequence Detail 1405 Not Applicable  
polypeptide ENSMUSP00000067662 Ensembl | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR011348 17beta-dehydrogenase
    IPR036291 NAD(P)-binding domain superfamily
    IPR020904 Short-chain dehydrogenase/reductase, conserved site
    IPR002347 Short-chain dehydrogenase/reductase SDR
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 1
    Phenotypes 37
  • Earliest
    J:99930 Maeda A, et al., Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13;280(19):18822-32
  • Latest
    J:262864 Chen Y, et al., A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 May 17;9(1):1976

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory