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Rdh8 Gene Detail
Summary
  • Symbol
    Rdh8
  • Name
    retinol dehydrogenase 8
  • Synonyms
    LOC235033, prRDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685028
    NCBI Gene: 235033
  • Gene Overview
    MyGene.info: RDH8
Location & Maps
more
  • Sequence Map
    Chr9:20818504-20826163 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7660 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.64 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RDH8, retinol dehydrogenase 8 (all-trans)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RDH8, retinol dehydrogenase 8 (all-trans)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRRDH, SDR28C2
  • Links
    NCBI Gene ID: 50700
    neXtProt AC: NX_Q9NYR8

  • Chr Location
    19p13.2; chr19:10013249-10022278 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
Homozygous null mice are viable and fertile but display delayed dark adaptation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 235033 NCBI Gene Model | MGI Sequence Detail 7660 C57BL/6J ±  kb
transcript NM_001030290 RefSeq | MGI Sequence Detail 1450 Not Specified  
polypeptide NP_001025461 RefSeq | MGI Sequence Detail 317 Not Specified  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    96 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR011348 17beta-dehydrogenase
    IPR016040 NAD(P)-binding domain
    IPR020904 Short-chain dehydrogenase/reductase, conserved site
    IPR002347 Short-chain dehydrogenase/reductase SDR
Molecular
Reagents
less
  • All nucleic 2
    Other 2

    Microarray probesets 1
References
more
  • Summaries
    All 40
    Diseases 1
    Gene Ontology 1
    Phenotypes 30
  • Earliest
    J:99930 Maeda A, et al., Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13;280(19):18822-32
  • Latest
    J:230948 Schur RM, et al., Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4936-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory