Rdh8
Gene Detail

Symbol Name ID

Rdh8 retinol dehydrogenase 8 MGI:2685028

Synonyms

LOC235033, prRDH

Feature Type

protein coding gene

Genetic Map

Chromosome 9

7.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:20818504-20826163 bp, + strand From NCBI annotation of GRCm38   7660 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: estradiol 17beta-dehydrogenase
Gene Tree: Rdh8

Human homologs

Human Homolog		RDH8, retinol dehydrogenase 8 (all-trans)
NCBI Gene ID		50700
neXtProt AC		NX_Q9NYR8
Human Synonyms		PRRDH, SDR28C2
Human Chr (Location)		19p13.2; chr19:10123925-10132954 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice are viable and fertile but display delayed dark adaptation.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	oxidation-reduction process, retinol metabolic process, ...
Function	retinol dehydrogenase activity

External Resources: FuncBase

Expression

External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(2) Other(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000053773 (Evidence)
Entrez Gene	235033 (Evidence)
Consensus CDS Project	CCDS22884.1
International Mouse Knockout Project Status	Rdh8

Sequences

Length	Strain/Species
genomic	235033	NCBI Gene Model | MGI Sequence Detail	7660	C57BL/6J
transcript	NM_001030290	RefSeq | MGI Sequence Detail	1450	Not Specified
polypeptide	NP_001025461	RefSeq | MGI Sequence Detail	317	Not Specified

All sequences(9) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011348	17beta-dehydrogenase
InterPro	IPR002347	Glucose/ribitol dehydrogenase
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR020904	Short-chain dehydrogenase/reductase, conserved site
InterPro	IPR002198	Short-chain dehydrogenase/reductase SDR
Protein Ontology	PR:000013855	retinol dehydrogenase 8

References

(Earliest) J:99930 Maeda A, et al., Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13;280(19):18822-32
(Latest) J:188863 Chen C, et al., Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12. J Biol Chem. 2012 Jul 13;287(29):24662-70
All references(30)