About   Help   FAQ
Rdh8
Gene Detail
 Symbol
Name
ID
Rdh8
retinol dehydrogenase 8
MGI:2685028
Synonyms LOC235033, prRDH
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:20818504-20826163 bp, + strand
From NCBI annotation of GRCm38

  7660 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: estradiol 17beta-dehydrogenase
Gene Tree: Rdh8

Human
homologs
Human Homolog RDH8, retinol dehydrogenase 8 (all-trans)
NCBI Gene ID 50700
neXtProt AC  NX_Q9NYR8
Human Synonyms  PRRDH, SDR28C2
Human Chr (Location)  19p13.2; chr19:10013249-10022278 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous null mice are viable and fertile but display delayed dark adaptation.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Rdh8 interacts with 81 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process oxidation-reduction process, retinol metabolic process, ...
Function retinol dehydrogenase activity
External Resources: FuncBase
Expression
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(2) Other(2)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000053773 (Evidence)
Entrez Gene235033 (Evidence)
Consensus CDS ProjectCCDS22884.1
International Mouse Knockout Project StatusRdh8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 235033 NCBI Gene Model | MGI Sequence Detail 7660 C57BL/6J ±  kb
transcript NM_001030290 RefSeq | MGI Sequence Detail 1450 Not Specified 
polypeptide NP_001025461 RefSeq | MGI Sequence Detail 317 Not Specified 

For the selected sequences
All sequences(9) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011348 17beta-dehydrogenase
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000013855 retinol dehydrogenase 8
References (Earliest) J:99930 Maeda A, et al., Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13;280(19):18822-32
(Latest) J:210001 Kohno H, et al., CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol. 2014 Apr 15;192(8):3816-27
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory