Cog7 MGI Mouse Gene Detail - MGI:2685013 - component of oligomeric golgi complex 7

Symbol

Cog7
Name

component of oligomeric golgi complex 7
Synonyms

5630400E24Rik

Feature Type

protein coding gene
IDs

MGI:2685013
NCBI Gene: 233824
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:121522059-121580940 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 65.09 cM
Mapping Data

1 experiment

SNPs within 2kb

458 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685013	protein coding gene	Chr7:121478586-121580940 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032946	protein coding gene	Chr7:125927583-126038856 (-)
A/J	MGP_AJ_G0032929	protein coding gene	Chr7:122668196-122774807 (-)
AKR/J	MGP_AKRJ_G0032861	protein coding gene	Chr7:125792426-125896784 (-)
BALB/cJ	MGP_BALBcJ_G0032934	protein coding gene	Chr7:122365290-122467739 (-)
C3H/HeJ	MGP_C3HHeJ_G0032644	protein coding gene	Chr7:125717604-125826144 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033440	protein coding gene	Chr7:130907465-131023928 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030412	protein coding gene	Chr7:123997054-124101300 (-)
CAST/EiJ	MGP_CASTEiJ_G0031972	protein coding gene	Chr7:117485218-117596330 (-)
CBA/J	MGP_CBAJ_G0032617	protein coding gene	Chr7:135275023-135402056 (-)
DBA/2J	MGP_DBA2J_G0032769	protein coding gene	Chr7:120681021-120782707 (-)
FVB/NJ	MGP_FVBNJ_G0032722	protein coding gene	Chr7:120530547-120633442 (-)
LP/J	MGP_LPJ_G0032863	protein coding gene	Chr7:127380079-127491002 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032754	protein coding gene	Chr7:136691190-136798968 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033460	protein coding gene	Chr7:124797633-124903099 (-)
PWK/PhJ	MGP_PWKPhJ_G0031680	protein coding gene	Chr7:113605816-113710069 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031526	protein coding gene	Chr7:111563261-111673235 (-)
WSB/EiJ	MGP_WSBEiJ_G0032085	protein coding gene	Chr7:125706256-125811233 (-)

Human Ortholog

COG7, component of oligomeric golgi complex 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COG7, component of oligomeric golgi complex 7
Synonyms

CDG2E
Links

HGNC:18622

NCBI Gene ID: 91949

neXtProt AC: NX_P83436

UniProt: P83436
Chr Location

16p12.2; chr16:23388493-23453189 (-) GRCh38

MGI Vertebrate Homology

Cog7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COG7
Gene Tree

Cog7

Diseases

2 with human COG7 associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation type IIe IDs congenital disorder of glycosylation type IIe DOID:0070257 MESH:C535754 OMIM:608779 ORDO:79333 UMLS_CUI:C2931010
				genetic disease IDs genetic disease DOID:630 MESH:D030342 NCI:C3101 UMLS_CUI:C0019247

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available

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All GO Annotations

18
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

5
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cog7

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All Sequences

46
RefSeq

8
UniProt

3
CCDS

CCDS21805.1

Ensembl

ENSMUSG00000034951 (Evidence)
NCBI Gene

233824

			Length	Strain/Species	Flank
genomic	233824	NCBI Gene Model \| MGI Sequence Detail	58882	C57BL/6J	± kb
transcript	NM_001033318	RefSeq \| MGI Sequence Detail	2884	NOD
polypeptide	Q3UM29	UniProt \| EBI \| MGI Sequence Detail	770	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005690 conserved oligomeric Golgi complex subunit 7

(term hierarchy)
InterPro Domains

IPR019335 Conserved oligomeric Golgi complex subunit 7

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All nucleic 15

cDNA 15

Microarray probesets 1

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
Latest

J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

TSS for Cog7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74565	Chr7:121580930-121580942 (-)	4 bp
Tssr74564	Chr7:121580892-121580929 (-)	29 bp
Tssr74563	Chr7:121580790-121580800 (-)	145 bp
Tssr74562	Chr7:121546361-121546365 (-)	34,577 bp
Tssr74561	Chr7:121545579-121545592 (-)	35,354 bp
Tssr74560	Chr7:121545503-121545549 (-)	35,414 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23