About   Help   FAQ
Dchs1
Gene Detail
 Symbol
Name
ID
Dchs1
dachsous 1 (Drosophila)
MGI:2685011
Synonyms 3110041P15Rik, C130033F22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 7
55.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:105752990-105787654 bp, - strand
From VEGA annotation of GRCm38

  34665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2771  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Dchs1

Human
homologs
Human Homolog DCHS1, dachsous cadherin-related 1
NCBI Gene ID 8642
neXtProt AC  NX_Q96JQ0
Human Synonyms  CDH19, CDH25, CDHR6, FIB1, PCDH16, VMLDS1
Human Chr (Location)  11p15.4; chr11:6621324-6664089 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DCHS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities.
 
Interactions
Dchs1 interacts with 360 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process branching involved in ureteric bud morphogenesis, cell adhesion, ...
Component apical part of cell, integral component of membrane, ...
Function calcium ion binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (22)    Images (12)
Theiler Stages: 20, 22, 28
Assay TypeResults
RNA in situ 14
RT-PCR 10
cDNA source data(103)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(105) cDNA(103) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014997 (Evidence)
Ensembl Gene ModelENSMUSG00000036862 (Evidence)
Entrez Gene233651 (Evidence)
UniGene334108
DFCITC1604193, TC1604844
DoTSDT.101392146, DT.480914
NIA Mouse Gene IndexU029045
Consensus CDS ProjectCCDS52351.1
International Mouse Knockout Project StatusDchs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014997 VEGA Gene Model | MGI Sequence Detail 34665 C57BL/6J ±  kb
transcript OTTMUST00000035612 VEGA | MGI Sequence Detail 10771 Not Applicable 
polypeptide OTTMUSP00000015964 VEGA | MGI Sequence Detail 2563 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(7) UniProt(4)
Polymorphisms SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR015919 Cadherin-like
Protein Ontology PR:000006306 protocadherin-16
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205294 Cappello S, et al., Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development. Nat Genet. 2013 Nov;45(11):1300-8
All references(32)
Other
accession IDs
MGI:1920409

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory