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Dchs1 Gene Detail
Summary
  • Symbol
    Dchs1
  • Name
    dachsous 1 (Drosophila)
  • Synonyms
    3110041P15Rik, C130033F22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685011
    NCBI Gene: 233651
  • Gene Overview
    MyGene.info: DCHS1
Location & Maps
more
  • Sequence Map
    Chr7:105752990-105787654 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34665 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 55.98 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DCHS1, dachsous cadherin-related 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DCHS1, dachsous cadherin-related 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDH19, CDH25, CDHR6, FIB1, MVP2, PCDH16, VMLDS1
  • Links
    NCBI Gene ID: 8642
    neXtProt AC: NX_Q96JQ0

  • Chr Location
    11p15.4; chr11:6621324-6655849 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dchs1 mouse models; 2 with human DCHS1 associations

Human Disease Mouse Models
       Mitral Valve Prolapse 1; MVP1   OMIM: 157700 View 1 model
       Mitral Valve Prolapse 2; MVP2   OMIM: 607829
Van Maldergem Syndrome 1; VMLDS1   OMIM: 601390
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Dchs1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014997 VEGA Gene Model | MGI Sequence Detail 34665 C57BL/6J ±  kb
transcript OTTMUST00000035612 VEGA | MGI Sequence Detail 10754 Not Applicable  
polypeptide OTTMUSP00000015964 VEGA | MGI Sequence Detail 3291 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    200 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 105
    cDNA 103
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920409
References
more
  • Summaries
    All 32
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:230957 Sugiyama Y, et al., Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation. Invest Ophthalmol Vis Sci. 2015 Jun;56(6):4099-107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory