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Cytl1 Gene Detail
Summary
  • Symbol
    Cytl1
  • Name
    cytokine-like 1
  • Synonyms
    4930443F05Rik, C17
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684993
    NCBI Gene: 231162
Location & Maps
more
  • Sequence Map
    Chr5:37735519-37739820 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4302 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CYTL1, cytokine like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CYTL1, cytokine like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C17, C4orf4
  • Links
    NCBI Gene ID: 54360
    neXtProt AC: NX_Q9NRR1

  • Chr Location
    4p16-p15; chr4:5014586-5019470 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    6 involving Cytl1
Mice homozygous for a knock-out allele exhibit increased susceptibility to osteoarthritic cartilage destruction following destabilization of the medial meniscus surgery.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056099 VEGA Gene Model | MGI Sequence Detail 4302 C57BL/6J ±  kb
transcript OTTMUST00000138714 VEGA | MGI Sequence Detail 974 Not Applicable  
polypeptide OTTMUSP00000072887 VEGA | MGI Sequence Detail 139 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    105 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR029253 Cytokine-like protein 1
Molecular
Reagents
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  • All nucleic 13
    cDNA 9
    Primer pair 3
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 25
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 3
    Phenotypes 22
  • Earliest
    J:92176 Ficker M, et al., Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Dev Biol. 2004 Apr 1;268(1):7-23
  • Latest
    J:224585 Jenner F, et al., Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos. Stem Cells Dev. 2014 Aug 15;23(16):1883-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory