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Cytl1
Gene Detail
Symbol

Name
ID
Cytl1
cytokine-like 1
MGI:2684993
Synonyms
4930443F05Rik, C17
Feature Type
protein coding gene
Genetic Map
Chromosome 5
20.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:37735519-37739820 bp, + strand
From NCBI annotation of GRCm38

  4302 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10254  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Cytl1

Human
homologs
Human Homolog CYTL1, cytokine-like 1
NCBI Gene ID 54360
neXtProt AC  NX_Q9NRR1
Human Synonyms  C17, C4orf4
Human Chr (Location)  4p16-p15; chr4:5014586-5019470 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(3)
Genomic Mutations involving Cytl1 (2)
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to osteoarthritic cartilage destruction following destabilization of the medial meniscus surgery.
 
Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Cytl1 interacts with 75 markers (Mir18, Mir18b, Mir132, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cartilage homeostasis, chondrocyte differentiation, ...
Component cellular_component
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (269)    Tissues (67)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 250
Northern blot 1
RT-PCR 18
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(9) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000062329 (Evidence)
Entrez Gene231162 (Evidence)
UniGene76407
DFCITC1611643, TC1629557
DoTSDT.55168068, DT.99855097
NIA Mouse Gene IndexU005523
Consensus CDS ProjectCCDS39077.1
International Mouse Knockout Project StatusCytl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 231162 NCBI Gene Model | MGI Sequence Detail 4302 C57BL/6J ±  kb
transcript NM_001081106 RefSeq | MGI Sequence Detail 974 Not Specified 
polypeptide NP_001074575 RefSeq | MGI Sequence Detail 139 Not Specified 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000006158 cytokine-like protein 1
References
(Earliest) J:92176 Ficker M, et al., Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Dev Biol. 2004 Apr 1;268(1):7-23
(Latest) J:175377 Jeon J, et al., Cytokine-like 1 knock-out mice (Cytl1-/-) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destruction. J Biol Chem. 2011 Aug 5;286(31):27206-13
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory