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Cytl1
Gene Detail
Symbol

Name
ID
Cytl1
cytokine-like 1
MGI:2684993
Synonyms
4930443F05Rik, C17
Feature Type
protein coding gene
Genetic Map
Chromosome 5
20.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:37735519-37739820 bp, + strand
From VEGA annotation of GRCm38

  4302 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10254  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CYTL1
Gene Tree: Cytl1

Human
homologs
CYTL1, cytokine-like 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54360
neXtProt AC: NX_Q9NRR1

Human Synonyms: C17, C4orf4

Human Chr (Location): 4p16-p15; chr4:5014586-5019470 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Radiation induced(2) Targeted(3)
Genomic Mutations involving Cytl1 (3)
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to osteoarthritic cartilage destruction following destabilization of the medial meniscus surgery.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(5)
Interactions
Cytl1 interacts with 74 markers (Mir18, Mir18b, Mir132, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cartilage homeostasis, chondrocyte differentiation, ...
Component cellular_component
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (269)    Tissues (67)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 250
Northern blot 1
RT-PCR 18
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cytl1    NEW 
Molecular
reagents
All nucleic(13) cDNA(9) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000056099 (Evidence)
Ensembl Gene Model ENSMUSG00000062329 (Evidence)
Entrez Gene 231162 (Evidence)
UniGene 76407
DFCI TC1611643, TC1629557
DoTS DT.55168068, DT.99855097
NIA Mouse Gene Index U005523
Consensus CDS Project CCDS39077.1
International Mouse Phenotyping Consortium Status Cytl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056099 VEGA Gene Model | MGI Sequence Detail 4302 C57BL/6J ±  kb
transcript OTTMUST00000138714 VEGA | MGI Sequence Detail 974 Not Applicable 
polypeptide OTTMUSP00000072887 VEGA | MGI Sequence Detail 139 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029253 Cytokine-like protein 1
Protein Ontology PR:000006158 cytokine-like protein 1
References
(Earliest) J:92176 Ficker M, et al., Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Dev Biol. 2004 Apr 1;268(1):7-23
(Latest) J:175377 Jeon J, et al., Cytokine-like 1 knock-out mice (Cytl1-/-) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destruction. J Biol Chem. 2011 Aug 5;286(31):27206-13
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory