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Pex10 Gene Detail
Summary
  • Symbol
    Pex10
  • Name
    peroxisomal biogenesis factor 10
  • Synonyms
    LOC230983, peroxisome biogenesis factor 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684988
    NCBI Gene: 668173
  • Gene Overview
    MyGene.info: PEX10
Location & Maps
more
  • Sequence Map
    Chr4:155067016-155072433 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5418 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 86.17 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PEX10, peroxisomal biogenesis factor 10
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PEX10, peroxisomal biogenesis factor 10
    Orthology source: HomoloGene
  • Synonyms
    NALD, PBD6A, PBD6B, RNF69
  • Links
    NCBI Gene ID: 5192
    neXtProt AC: NX_O60683

  • Chr Location
    1p36.32; chr1:2404802-2413780 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Pex10 mouse models; 2 with human PEX10 associations

Human Disease Mouse Models
       Peroxisome Biogenesis Disorder 6a (zellweger); PBD6A   OMIM: 614870 View 1 model
Peroxisome Biogenesis Disorder 6b; PBD6B   OMIM: 614871 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for an ENU-induced allele exhibit partial neonatal mortality due to respiratory distress, loss of embryonic movement, and prenatal pathology including altered biochemistry, defects in axonal integrity, decreased Schwann cell number, and defects at the neuromuscular junction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010596 VEGA Gene Model | MGI Sequence Detail 5418 C57BL/6J ±  kb
transcript OTTMUST00000024731 VEGA | MGI Sequence Detail 1688 Not Applicable  
polypeptide OTTMUSP00000011353 VEGA | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012554 peroxisome biogenesis factor 10
  • InterPro Domains
    IPR025654 Peroxisome biogenesis factor 10
    IPR006845 Pex, N-terminal
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
    IPR017907 Zinc finger, RING-type, conserved site
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 2
Other
Accession IDs
less
MGI:3034175
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:216140 Hanson MG, et al., Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. Dev Biol. 2014 Nov 1;395(1):84-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory