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Mms22l Gene Detail
Summary
  • Symbol
    Mms22l
  • Name
    MMS22-like, DNA repair protein
  • Synonyms
    F730047E07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684980
    NCBI Gene: 212377
  • Gene Overview
    MyGene.info: MMS22L
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:24496451-24602950 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 10.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    650 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684980
protein coding gene Chr4:24496224-24602950 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028098
protein coding gene Chr4:21601973-21712644 (+)
A/J MGP_AJ_G0028056
protein coding gene Chr4:20958589-21064981 (+)
AKR/J MGP_AKRJ_G0028021
protein coding gene Chr4:21426535-21542458 (+)
BALB/cJ MGP_BALBcJ_G0028067
protein coding gene Chr4:21019211-21130319 (+)
C3H/HeJ MGP_C3HHeJ_G0027797
protein coding gene Chr4:21611413-21740916 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028510
protein coding gene Chr4:22496313-22617333 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025852
protein coding gene Chr4:19452245-19556864 (+)
CAST/EiJ MGP_CASTEiJ_G0027252
protein coding gene Chr4:21335683-21484188 (+)
CBA/J MGP_CBAJ_G0027770
protein coding gene Chr4:23167745-23279630 (+)
DBA/2J MGP_DBA2J_G0027913
protein coding gene Chr4:20848702-20973204 (+)
FVB/NJ MGP_FVBNJ_G0027879
protein coding gene Chr4:20510013-20616832 (+)
LP/J MGP_LPJ_G0028022
protein coding gene Chr4:21706976-21816013 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027912
protein coding gene Chr4:24610991-24728757 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028569
protein coding gene Chr4:21409872-21516515 (+)
PWK/PhJ MGP_PWKPhJ_G0026972
protein coding gene Chr4:20589029-20720345 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026801
protein coding gene Chr4:21153770-21262785 (+)
WSB/EiJ MGP_WSBEiJ_G0027329
protein coding gene Chr4:21338806-21452426 (+)



Homology
more
  • Human Ortholog
    MMS22L, MMS22 like, DNA repair protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MMS22L, MMS22 like, DNA repair protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C6orf167, dJ39B17.2
  • Links
    NCBI Gene ID: 253714
    neXtProt AC: NX_Q6ZRQ5
    UniProt: Q6ZRQ5

  • Chr Location
    6q16.1; chr6:97142161-97283437 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18874
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MMS22L
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation die prenatally. Heterozygous mice exhibit defects in pinna responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045751 Ensembl Gene Model | MGI Sequence Detail 106500 C57BL/6J ±  kb
transcript ENSMUST00000108222 Ensembl | MGI Sequence Detail 4478 Not Applicable  
polypeptide ENSMUSP00000103857 Ensembl | MGI Sequence Detail 1238 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    cDNA 54

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory