Man1b1
Gene Detail

Symbol Name ID

Man1b1 mannosidase, alpha, class 1B, member 1 MGI:2684954

Synonyms

E430019H13Rik, LOC227619, MANA-ER

Feature Type

protein coding gene

Genetic Map

Chromosome 2

17.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:25332338-25352212 bp, + strand From VEGA annotation of GRCm38   19875 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5230  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: mannosyl-oligosaccharide 1,2-alpha-mannosidase, 1A type
Gene Tree: Man1b1

Human homologs

Human Homolog		MAN1B1, mannosidase, alpha, class 1B, member 1
NCBI Gene ID		11253
neXtProt AC		NX_Q9UKM7
Human Synonyms		ERMAN1, MANA-ER, MRT15
Human Chr (Location)		9q34; chr9:139981379-140003639 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAN1B1

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	ER-associated protein catabolic process, metabolic process
Component	endoplasmic reticulum, integral to membrane, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(84)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(85) cDNA(84) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000011996 (Evidence)
Ensembl Gene Model	ENSMUSG00000036646 (Evidence)
Entrez Gene	227619 (Evidence)
UniGene	270798
DFCI	TC1575229, TC1595495
DoTS	DT.489471, DT.91298541
NIA Mouse Gene Index	U001486
EC	3.2.1.113
Consensus CDS Project	CCDS15765.1
International Mouse Knockout Project Status	Man1b1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011996	VEGA Gene Model | MGI Sequence Detail	19875	C57BL/6J
transcript	OTTMUST00000028418	VEGA | MGI Sequence Detail	3755	Not Applicable
polypeptide	OTTMUSP00000012873	VEGA | MGI Sequence Detail	658	Not Applicable

All sequences(56) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(100 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001382	Glycoside hydrolase, family 47
Protein Ontology	PR:000010103	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(29)