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Dnah7b Gene Detail
Summary
  • Symbol
    Dnah7b
  • Name
    dynein, axonemal, heavy chain 7B
  • Synonyms
    Dnahc7b, LOC227058
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684953
    NCBI Gene: 227058
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:46105475-46412710 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 23.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    955 from dbSNP Build 142
  • Strain Annotations
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684953
 protein coding gene Chr1:46105232-46412711 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0015936
 protein coding gene Chr1:43398997-43400062 (+)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    DNAH7, dynein axonemal heavy chain 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAH7, dynein axonemal heavy chain 7
  • Synonyms
    CILD50
  • Links
    NCBI Gene ID: 56171
    neXtProt AC: NX_Q8WXX0
    UniProt: Q8WXX0

  • Chr Location
    2q32.3; chr2:195737703-196068837 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DNAH7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041144 Ensembl Gene Model | MGI Sequence Detail 307236 C57BL/6J ±  kb
    transcript ENSMUST00000069293 Ensembl | MGI Sequence Detail 12318 Not Applicable  
    polypeptide ENSMUSP00000068738 Ensembl | MGI Sequence Detail 4068 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR026983 Dynein heavy chain
      IPR041589 Dynein heavy chain 3, AAA+ lid domain
      IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
      IPR041466 Dynein heavy chain, AAA 5 extension domain
      IPR041658 Dynein heavy chain AAA lid domain
      IPR042219 Dynein heavy chain AAA lid domain superfamily
      IPR024317 Dynein heavy chain, AAA module D4
      IPR035706 Dynein heavy chain, ATP-binding dynein motor region
      IPR024743 Dynein heavy chain, coiled coil stalk
      IPR041228 Dynein heavy chain, C-terminal domain
      IPR043160 Dynein heavy chain, C-terminal domain, barrel region
      IPR042222 Dynein heavy chain, domain 2, N-terminal
      IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
      IPR013602 Dynein heavy chain, linker
      IPR042228 Dynein heavy chain, linker, subdomain 3
      IPR004273 Dynein heavy chain region D6 P-loop domain
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:208266 Dong F, et al., Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. J Cell Biol. 2014 Jan 20;204(2):203-13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory