Tdrd5 MGI Mouse Gene Detail - MGI:2684949 - tudor domain containing 5

Symbol

Tdrd5
Name

tudor domain containing 5

Feature Type

protein coding gene
IDs

MGI:2684949
NCBI Gene: 214575
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:156082866-156131234 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 67.71 cM, cytoband G3
Mapping Data

2 experiments

SNPs within 2kb

577 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684949	protein coding gene	Chr1:156082866-156131874 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016621	protein coding gene	Chr1:161188505-161246462 (-)
A/J	MGP_AJ_G0016602	protein coding gene	Chr1:154720472-154768704 (-)
AKR/J	MGP_AKRJ_G0016568	protein coding gene	Chr1:159451010-159499890 (-)
BALB/cJ	MGP_BALBcJ_G0016563	protein coding gene	Chr1:155218747-155267101 (-)
C3H/HeJ	MGP_C3HHeJ_G0016387	protein coding gene	Chr1:159574901-159627030 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017024	protein coding gene	Chr1:166708338-166761059 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014733	protein coding gene	Chr1:146923430-146967600 (-)
CAST/EiJ	MGP_CASTEiJ_G0015967	protein coding gene	Chr1:159118601-159170667 (-)
CBA/J	MGP_CBAJ_G0016362	protein coding gene	Chr1:172586587-172635998 (-)
DBA/2J	MGP_DBA2J_G0016468	protein coding gene	Chr1:153677991-153726096 (-)
FVB/NJ	MGP_FVBNJ_G0016466	protein coding gene	Chr1:152132857-152180035 (-)
LP/J	MGP_LPJ_G0016539	protein coding gene	Chr1:162316346-162365584 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016491	protein coding gene	Chr1:180163599-180213196 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017060	protein coding gene	Chr1:159246640-159297024 (-)
PWK/PhJ	MGP_PWKPhJ_G0015753	protein coding gene	Chr1:152755149-152802794 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015540	protein coding gene	Chr1:157996958-158050850 (-)
WSB/EiJ	MGP_WSBEiJ_G0016029	protein coding gene	Chr1:159346465-159395707 (-)

Human Ortholog

TDRD5, tudor domain containing 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TDRD5, tudor domain containing 5
Synonyms

TUDOR3
Links

HGNC:20614

NCBI Gene ID: 163589

neXtProt AC: NX_Q8NAT2

UniProt: Q8NAT2
Chr Location

1q25.2; chr1:179591613-179691272 (+) GRCh38

MGI Vertebrate Homology

Tdrd5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TDRD5
Gene Tree

Tdrd5

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
2 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

2 involving Tdrd5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility associated with defective spermatid elongation, occasional arrested male meiosis, and apoptosis of male germ cells.

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All GO Annotations

11
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

855
Tissues

124
cDNA Data

15
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tdrd5

ZFIN tdrd5

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All Sequences

68
RefSeq

29
UniProt

3
CCDS

CCDS56647.1

Ensembl

ENSMUSG00000060985 (Evidence)
NCBI Gene

214575

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060985	Ensembl Gene Model \| MGI Sequence Detail	48369	C57BL/6J	± kb
transcript	ENSMUST00000121146	Ensembl \| MGI Sequence Detail	3759	Not Applicable
polypeptide	ENSMUSP00000137298	Ensembl \| MGI Sequence Detail	1040	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029783 tudor domain-containing protein 5

(term hierarchy)
InterPro Domains

IPR041966 LOTUS-like domain

IPR025605 OST-HTH/LOTUS domain

IPR035437 SNase-like, OB-fold superfamily

IPR037982 TDRD5, second LOTUS domain

IPR002999 Tudor domain

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All nucleic 19

cDNA 16

Primer pair 3

Microarray probesets 2

Summaries

All 32

Developmental Gene Expression 9

Gene Ontology 3

Phenotypes 7
Earliest

J:93161 Smith JM, et al., Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Gene Expr Patterns. 2004 Oct;4(6):701-5
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tdrd5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14426	Chr1:156131155-156131186 (-)	63 bp
Tssr14425	Chr1:156131142-156131147 (-)	89 bp
Tssr14424	Chr1:156130960-156131008 (-)	250 bp
Tssr14423	Chr1:156130932-156130958 (-)	289 bp
Tssr14422	Chr1:156107933-156107967 (-)	23,284 bp
Tssr14421	Chr1:156098392-156098399 (-)	32,838 bp
Tssr14420	Chr1:156098345-156098361 (-)	32,881 bp
Tssr14419	Chr1:156098334-156098337 (-)	32,898 bp
Tssr14418	Chr1:156098307-156098316 (-)	32,922 bp
Tssr14417	Chr1:156098258-156098269 (-)	32,970 bp
Tssr14416	Chr1:156098235-156098246 (-)	32,993 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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