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Tdrd5
Gene Detail
 Symbol
Name
ID
Tdrd5
tudor domain containing 5
MGI:2684949
Feature Type protein coding gene
Genetic Map
Chromosome 1
67.71 cM, cytoband G3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:156255296-156303664 bp, - strand
From VEGA annotation of GRCm38

  48369 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18312  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Tdrd5

Human
homologs
Human Homolog TDRD5, tudor domain containing 5
NCBI Gene ID 163589
neXtProt AC  NX_Q8NAT2
Human Synonyms  TUDOR3
Human Chr (Location)  1q25.2; chr1:179591613-179691272 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit male infertility associated with defective spermatid elongation, occasional arrested male meiosis, and apoptosis of male germ cell.
 
Phenotype Images(2)
Interactions
Tdrd5 interacts with 101 markers (Mir7-1, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell differentiation, DNA methylation involved in gamete generation, ...
Component chromatoid body, cytoplasm, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (148)    Tissues (125)    Images (24)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 122
Northern blot 8
RT-PCR 18
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(15) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000026427 (Evidence)
Ensembl Gene ModelENSMUSG00000060985 (Evidence)
Entrez Gene214575 (Evidence)
UniGene252800
DFCITC1611893
DoTSDT.101267553, DT.87068292, DT.91313848, DT.94246338
NIA Mouse Gene IndexU021927
Consensus CDS ProjectCCDS56647.1
International Mouse Knockout Project StatusTdrd5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026427 VEGA Gene Model | MGI Sequence Detail 48369 C57BL/6J ±  kb
transcript OTTMUST00000065358 VEGA | MGI Sequence Detail 3759 Not Applicable 
polypeptide OTTMUSP00000062799 VEGA | MGI Sequence Detail 1040 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(24) UniProt(3)
Polymorphisms SNPs within 2kb(582 from dbSNP Build 137)    SNPs within 2kb including multiple locations(586)
Protein-related
information
ResourceIDDescription
InterPro IPR025605 OST-HTH/LOTUS domain
InterPro IPR002999 Tudor domain
Protein Ontology PR:000029783 tudor domain-containing protein 5
References (Earliest) J:93161 Smith JM, et al., Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Gene Expr Patterns. 2004 Oct;4(6):701-5
(Latest) J:179634 Chassot AA, et al., RSPO1/beta-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS One. 2011;6(10):e25641
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory