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Tdrd5 Gene Detail
Summary
  • Symbol
    Tdrd5
  • Name
    tudor domain containing 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684949
    NCBI Gene: 214575
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:156255296-156303664 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 67.71 cM, cytoband G3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    585 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684949
protein coding gene Chr1:156255296-156305287 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016621
protein coding gene Chr1:161188505-161246462 (-)
A/J MGP_AJ_G0016602
protein coding gene Chr1:154720472-154768704 (-)
AKR/J MGP_AKRJ_G0016568
protein coding gene Chr1:159451010-159499890 (-)
BALB/cJ MGP_BALBcJ_G0016563
protein coding gene Chr1:155218747-155267101 (-)
C3H/HeJ MGP_C3HHeJ_G0016387
protein coding gene Chr1:159574901-159627030 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017024
protein coding gene Chr1:166708338-166761059 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014733
protein coding gene Chr1:146923430-146967600 (-)
CAST/EiJ MGP_CASTEiJ_G0015967
protein coding gene Chr1:159118601-159170667 (-)
CBA/J MGP_CBAJ_G0016362
protein coding gene Chr1:172586587-172635998 (-)
DBA/2J MGP_DBA2J_G0016468
protein coding gene Chr1:153677991-153726096 (-)
FVB/NJ MGP_FVBNJ_G0016466
protein coding gene Chr1:152132857-152180035 (-)
LP/J MGP_LPJ_G0016539
protein coding gene Chr1:162316346-162365584 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016491
protein coding gene Chr1:180163599-180213196 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017060
protein coding gene Chr1:159246640-159297024 (-)
PWK/PhJ MGP_PWKPhJ_G0015753
protein coding gene Chr1:152755149-152802794 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015540
protein coding gene Chr1:157996958-158050850 (-)
WSB/EiJ MGP_WSBEiJ_G0016029
protein coding gene Chr1:159346465-159395707 (-)



Homology
more
  • Human Ortholog
    TDRD5, tudor domain containing 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TDRD5, tudor domain containing 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TUDOR3
  • Links
    NCBI Gene ID: 163589
    neXtProt AC: NX_Q8NAT2
    UniProt: Q8NAT2

  • Chr Location
    1q25.2; chr1:179591613-179691272 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with defective spermatid elongation, occasional arrested male meiosis, and apoptosis of male germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060985 Ensembl Gene Model | MGI Sequence Detail 48369 C57BL/6J ±  kb
    transcript ENSMUST00000121146 Ensembl | MGI Sequence Detail 3759 Not Applicable  
    polypeptide ENSMUSP00000137298 Ensembl | MGI Sequence Detail 1040 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 7
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:93161 Smith JM, et al., Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Gene Expr Patterns. 2004 Oct;4(6):701-5
    • Latest
      J:255733 Ding D, et al., TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice. Nat Commun. 2018 Jan 9;9(1):127

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory