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Myrf Gene Detail
Summary
  • Symbol
    Myrf
  • Name
    myelin regulatory factor
  • Synonyms
    Gm98, LOC225908, LOC386531
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684944
    NCBI Gene: 225908
  • Gene Overview
    MyGene.info: MYRF
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10208272-10240748 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 6.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684944
protein coding gene Chr19:10208271-10240781 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024841
protein coding gene Chr19:7531680-7565462 (-)
A/J MGP_AJ_G0024809
protein coding gene Chr19:7015025-7047493 (-)
AKR/J MGP_AKRJ_G0024784
protein coding gene Chr19:7295374-7327839 (-)
BALB/cJ MGP_BALBcJ_G0024809
protein coding gene Chr19:7061789-7094274 (-)
C3H/HeJ MGP_C3HHeJ_G0024575
protein coding gene Chr19:7183005-7215489 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025257
protein coding gene Chr19:7878838-7918972 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022684
protein coding gene Chr19:7432968-7465247 (-)
CAST/EiJ MGP_CASTEiJ_G0024048
protein coding gene Chr19:6842942-6875194 (-)
CBA/J MGP_CBAJ_G0024549
protein coding gene Chr19:7926275-7960350 (-)
DBA/2J MGP_DBA2J_G0024676
protein coding gene Chr19:7028745-7061205 (-)
FVB/NJ MGP_FVBNJ_G0024643
protein coding gene Chr19:7066398-7099622 (-)
LP/J MGP_LPJ_G0024763
protein coding gene Chr19:7508186-7540662 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024670
protein coding gene Chr19:7834151-7866446 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025305
protein coding gene Chr19:7317981-7351628 (-)
PWK/PhJ MGP_PWKPhJ_G0023793
protein coding gene Chr19:6468916-6501524 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023598
protein coding gene Chr19:6505420-6537061 (-)
WSB/EiJ MGP_WSBEiJ_G0024110
protein coding gene Chr19:7201722-7235049 (-)



Homology
more
  • Human Ortholog
    MYRF, myelin regulatory factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYRF, myelin regulatory factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    11orf9, C11orf9, MMERV, MRF, Ndt80, pqn-47
  • Links
    NCBI Gene ID: 745
    neXtProt AC: NX_Q9Y2G1
    UniProt: Q9Y2G1

  • Chr Location
    11q12.2; chr11:61752617-61788518 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32167
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYRF
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036098 Ensembl Gene Model | MGI Sequence Detail 32477 C57BL/6J ±  kb
    transcript ENSMUST00000088013 Ensembl | MGI Sequence Detail 5674 Not Applicable  
    polypeptide ENSMUSP00000085329 Ensembl | MGI Sequence Detail 1138 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • PDB
    • EC
    • InterPro Domains
      IPR030392 Intramolecular chaperone auto-processing domain
      IPR026933 Myelin gene regulatory factor
      IPR026932 Myelin gene regulatory factor C-terminal domain 1
      IPR025719 Myelin gene regulatory factor C-terminal domain 2
      IPR024061 NDT80 DNA-binding domain
      IPR008967 p53-like transcription factor, DNA-binding
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 40

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2686650
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:260791 Truch K, et al., Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease. Hum Mol Genet. 2018 Mar 15;27(6):1078-1092

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory