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Cenpj Gene Detail
Summary
  • Symbol
    Cenpj
  • Name
    centromere protein J
  • Synonyms
    4932437H03Rik, Sas4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684927
    NCBI Gene: 219103
  • Gene Overview
    MyGene.info: CENPJ
Location & Maps
more
  • Sequence Map
    Chr14:56526761-56571846 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45086 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.28 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CENPJ, centromere protein J
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CENPJ, centromere protein J
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BM032, CENP-J, CPAP, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4
  • Links
    NCBI Gene ID: 55835
    neXtProt AC: NX_Q9HC77

  • Chr Location
    13q12.12-q12.13; chr13:24882274-24922889 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10204
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CENPJ
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Cenpj mouse models; 2 with human CENPJ associations

Human Disease Mouse Models
       Seckel Syndrome 4; SCKL4   OMIM: 613676 View 1 model
       Microcephaly 6, Primary, Autosomal Recessive; MCPH6   OMIM: 608393
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    81 phenotypes from 5 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    3 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    6
  • Genomic Mutations
    1 involving Cenpj
  • Incidental Mutations
Mice homozygous for null alleles exhibit embryonic lethality during early organogenesis and may show failure of embryo turning and absence of centrioles, cilia and centrosomes. Mice homozygous for a hypomorphic allele display partial lethality, dwarfism and a wide range of abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019769 VEGA Gene Model | MGI Sequence Detail 45086 C57BL/6J ±  kb
transcript OTTMUST00000047283 VEGA | MGI Sequence Detail 4363 Not Applicable  
polypeptide OTTMUSP00000021339 VEGA | MGI Sequence Detail 1344 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    127 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 42

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:78713 Peng B, et al., CPAP Is a Novel Stat5-Interacting Cofactor that Augments Stat5-Mediated Transcriptional Activity. Mol Endocrinol. 2002 Sep;16(9):2019-33
  • Latest
    J:221891 Garcez PP, et al., Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1. Nat Commun. 2015;6:6474

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory