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Cenpj
Gene Detail
Symbol

Name
ID
Cenpj
centromere protein J
MGI:2684927
Synonyms
4932437H03Rik, Sas4
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:56526761-56571846 bp, - strand
From VEGA annotation of GRCm38

  45086 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10204  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CENPJ
Gene Tree: Cenpj

Human
homologs
CENPJ, centromere protein J
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55835
neXtProt AC: NX_Q9HC77

Human Synonyms: BM032, CENP-J, CPAP, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4

Human Chr (Location): 13q12.12; chr13:24882274-24922889 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CENPJ

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for null alleles exhibit embryonic lethality during early organogenesis and may show failure of embryo turning and absence of centrioles, cilia and centrosomes. Mice homozygous for a hypomorphic allele display partial lethality, dwarfism and a wide range of abnormalities.
 
Human Diseases Modeled in Mice Using Cenpj (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Cenpj interacts with 85 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process astral microtubule nucleation, centriole replication, ...
Component centriole, centrosome, ...
Function gamma-tubulin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (162)    Tissues (21)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cenpj    NEW 
Molecular
reagents
All nucleic(42) cDNA(42)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000019769 (Evidence)
Ensembl Gene Model ENSMUSG00000064128 (Evidence)
Entrez Gene 219103 (Evidence)
UniGene 212525
DFCI TC1601334, TC1580032
DoTS DT.60117829, DT.94139632
NIA Mouse Gene Index U035609
Consensus CDS Project CCDS27150.1
International Mouse Phenotyping Consortium Status Cenpj
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019769 VEGA Gene Model | MGI Sequence Detail 45086 C57BL/6J ±  kb
transcript OTTMUST00000047283 VEGA | MGI Sequence Detail 4363 Not Applicable 
polypeptide OTTMUSP00000021339 VEGA | MGI Sequence Detail 1344 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009852 T-complex protein 10, C-terminal domain
InterPro IPR026581 T-complex protein 10 family
Protein Ontology PR:000005330 centromere protein J
References
(Earliest) J:78713 Peng B, et al., CPAP Is a Novel Stat5-Interacting Cofactor that Augments Stat5-Mediated Transcriptional Activity. Mol Endocrinol. 2002 Sep;16(9):2019-33
(Latest) J:219422 Insolera R, et al., Cortical neurogenesis in the absence of centrioles. Nat Neurosci. 2014 Nov;17(11):1528-35
All references(37)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory