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Cenpj
Gene Detail
Symbol

Name
ID
Cenpj
centromere protein J
MGI:2684927
Synonyms
4932437H03Rik, Sas4
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:56526761-56571846 bp, - strand
From VEGA annotation of GRCm38

  45086 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10204  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cenpj

Human
homologs
Human Homolog CENPJ, centromere protein J
NCBI Gene ID 55835
neXtProt AC  NX_Q9HC77
Human Synonyms  BM032, CENP-J, CPAP, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4
Human Chr (Location)  13q12.12; chr13:24882274-24922889 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CENPJ
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice exhibit embryonic lethality at about E8.5.
 
Human Diseases Modeled Using Mouse Cenpj (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Cenpj interacts with 85 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process astral microtubule nucleation, centriole replication, ...
Component centriole, centrosome, ...
Function gamma-tubulin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (162)    Tissues (21)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(42)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000019769 (Evidence)
Ensembl Gene ModelENSMUSG00000064128 (Evidence)
Entrez Gene219103 (Evidence)
UniGene212525
DFCITC1580032, TC1601334
DoTSDT.94139632, DT.60117829
NIA Mouse Gene IndexU035609
Consensus CDS ProjectCCDS27150.1
International Mouse Knockout Project StatusCenpj
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019769 VEGA Gene Model | MGI Sequence Detail 45086 C57BL/6J ±  kb
transcript OTTMUST00000047283 VEGA | MGI Sequence Detail 4363 Not Applicable 
polypeptide OTTMUSP00000021339 VEGA | MGI Sequence Detail 1344 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009852 T-complex protein 10, C-terminal domain
InterPro IPR026581 T-complex protein 10 family
Protein Ontology PR:000005330 centromere protein J
References
(Earliest) J:78713 Peng B, et al., CPAP Is a Novel Stat5-Interacting Cofactor that Augments Stat5-Mediated Transcriptional Activity. Mol Endocrinol. 2002 Sep;16(9):2019-33
(Latest) J:208632 Bazzi H, et al., Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1491-500
All references(36)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory